Gabapentin Dosing - Neurontin Renal Dosing

Usual Gabapentin Dosing (Adults)

Usual initial gabapentin dose: 300mg q8h. Usual maintenance dose: 300-600mg q8h. Maximum dosage/day: 3600 mg

Gabapentin Renal Dosing

[>60 ml/min]: Give usual dosage

[30-59]: Dosage range: 400-1400mg/day
(divided doses - Usually bid)

[15-29]: Dosage range: 200-700mg/day.

[<15]: 100-300 mg/day. Use lower end of this range for CRCL <7.5 ml/min.

Hemodialysis

supplemental gabapentin dose after dialysis

Hemodialysis:
[<15 ml/min]: 100-300 mg/day. Give supplemental gabapentin dose of 125-350mg after each dialysis. Dosage given should be proportional to maintenance gabapentin dose. Patients receiving at least 300mg/day can be given the higher supplemental dose of 350mg after each dialysis. Other patients should receive gabapentin dosage at the lower end of this range.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates. A local search option of this data can be found here.