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Primidone - Mysoline ® - Renal Dosing

Usual Dosing (Adults)

Seizure disorders: Initial: 125-250 mg/day orally at bedtime. Increase by 125 to 250 mg/day q3-7 days. Usual dose: 750-1500 mg/day in divided doses 3-4 times/day. Maximum dosage: 2 grams/day.

Renal Dosing

dialysis [CRCL 50-80 ml/min]: give q8h

[10-50]: Give q 8-12 hours.

[ <10 ]: Give q12-24 hours.

Hemodialysis

dialysis Dose as for CrCl<10  - on dialysis days supplement with 1/3 of usual dose AD

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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