Diabetic peripheral neuropathy:
initial: 50 mg po tid - may be increased to 100mg tid within 1 week based on
efficacy and tolerability.
initial 75 mg po bid OR 50 mg po tid - may be increased to 300 mg/day within 1
week based on efficacy and tolerability.
Maintenance: 75 to 150 mg po bid or 50 - 100 mg po tid (150 to 300 mg/day). Lack
of effect: patients who do not experience sufficient pain relief following 2 to
4 weeks of treatment with 300 mg/day and are tolerating pregabalin, may increase
dosage up to 300mg bid, or 200mg tid.
[>60 ml/min]: No changes
[30-60]: 75 to 300 mg/day in 2 to 3 divided doses.
[15-30]: 25 to 150 mg/day given qd or in 2 divided doses.
[<15 ml/min]: 25 to 75 mg qd.
Hemodialysis: (supplemental dose to be taken immediately following
4-hour dialysis session) Current regimen:
25 mg qd + Supplemental dose of 25mg or 50 mg Post HD
25 to 50 mg qd + Supplemental dose of 50 mg or 75 mg Post
75mg qd + Supplemental dose of 100 mg or 150 mg Post HD.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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