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Pregabalin - Lyrica ® - Renal Dosing

Usual Dosing (Adults)

Diabetic peripheral neuropathy: 
initial: 50 mg po tid - may be increased to 100mg tid within 1 week based on efficacy and tolerability. 

Postherpetic neuralgia: 
initial 75 mg po bid OR 50 mg po tid - may be increased to 300 mg/day within 1 week based on efficacy and tolerability.  
Maintenance: 75 to 150 mg po bid or 50 - 100 mg po tid (150 to 300 mg/day). Lack of effect: patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day and are tolerating pregabalin, may increase dosage up to 300mg bid, or 200mg tid. 

Renal Dosing

dialysis [>60 ml/min]: No changes
[30-60]: 75 to 300 mg/day in 2 to 3 divided doses.
[15-30]: 25 to 150 mg/day given qd or in 2 divided doses.
[<15 ml/min]: 25 to 75 mg qd.

Hemodialysis

dialysis Hemodialysis:  (supplemental dose to be taken immediately following 4-hour dialysis session)
Current regimen:
25 mg qd + Supplemental dose of 25mg or  50 mg Post HD
25 to 50 mg qd + Supplemental dose of  50 mg or 75 mg Post HD. 
75mg qd + Supplemental dose of 100 mg or 150 mg Post HD.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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