kinetics

Advanced Pharmacokinetic Dosing Calculator
 pharmacokinetic dosing

Patient-Specific Data
Patient:     Location:
Age:     Sex:     Serum Creatinine:   
Height:     Weight:

Select method used to calculate creatinine clearance:

If using MDRD specify race:

Drug Selection, Levels, and Drug-specific PK Parameters:

Select Drug:   Desired Peak:    Desired Trough:
Volume of distribution:   L/kg
Usual range: aminoglycosides: 0.25-0.35.  Vanco: 0.65 - 0.9   		Infusion time (ti):   Additional Info
Select desired Empiric Kel Formula (VANCOMYCIN only):  

Amputations (Optional Field)

Loading Dose (optional)-Aminoglycosides

Process form entries
Cockcroft and Gault equation utilizing the adjusted body weight to calculate an estimated creatinine clearance.
pharmacokinetics

CrCl = [(140 - age) x AjBW] / (Scr x 72)

Note: (Multiply result by 0.85 for females)
AjBW = adjusted body weight:
AjBW = IBW + 0.4( ABW - IBW)

Estimated IBW:
Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.

Some studies have shown that utilizing the adjusted body weight improves accuracy compared to other commonly used equations in estimating the creatinine clearance in the elderly population.
Cockcroft and Gault equation utilizing the ibw (Ideal body weight) to calculate an estimated creatinine clearance
Cockcroft and Gault equation:
CrCl = [(140 - age) x IBW] / (Scr x 72) (x 0.85 for females)
Note: if the ABW (actual body weight) is less than the IBW use the
actual body weight for calculating the CRCL.

Estimate Ideal body weight in (kg)
Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.
Simplified 4-variable MDRD study formula
GFR = 186.3 x (SCR)-1.154  x  (age in years)-0.203  x  1.212 (if patient is black)  x 0.742 (if female)

Key point: Early statistical analysis shows very promising results. May represent the most accurate choice of this group. This may be especially true in chronic kidney disease.