﻿ Pharmacokinetics - Pharmacokinetic Dosing - Aminoglycosides / Vancomycin

#### Patient-Specific Data

Patient:     Location:
Age:     Sex    Serum Creatinine
Height:     Weight:

#### Select method used to calculate creatinine clearance:

If using MDRD specify race:

#### Drug Selection, Levels, and Drug-specific PK Parameters:

Select Drug:   Desired Peak:    Desired Trough:
Volume of distribution:   L/kg
Usual range: aminoglycosides: 0.25-0.35.  Vanco: 0.65 - 0.9
Select desired Empiric Kel Formula (VANCOMYCIN only):

(optional)

#### Process form entries

Cockcroft and Gault equation utilizing the adjusted body weight to calculate an estimated creatinine clearance.
CrCl = [(140 - age) x AjBW] / (Scr x 72)

Note: (Multiply result by 0.85 for females)
AjBW = IBW + 0.4( ABW - IBW)

Estimated IBW:
Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.

Some studies have shown that utilizing the adjusted body weight improves accuracy compared to other commonly used equations in estimating the creatinine clearance in the elderly population.
Cockcroft and Gault equation utilizing the ibw (Ideal body weight) to calculate an estimated creatinine clearance
Cockcroft and Gault equation:
CrCl = [(140 - age) x IBW] / (Scr x 72) (x 0.85 for females)
Note: if the ABW (actual body weight) is less than the IBW use the
actual body weight for calculating the CRCL.

Estimate Ideal body weight in (kg)
Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.
Simplified 4-variable MDRD study formula
GFR = 186.3 x (SCR)-1.154  x  (age in years)-0.203  x  1.212 (if patient is black)  x 0.742 (if female)

Key point: Early statistical analysis shows very promising results. May represent the most accurate choice of this group. This may be especially true in chronic kidney disease.

## Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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