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Pancuronium Pavulon ® - Renal dosing

Usual Dosing (Adults)

Neuromuscular blockade: Initial: 0.06-0.1 mg/kg or 0.05 mg/kg after initial dose of succinylcholine for intubation; maintenance dose: 0.01 mg/kg 60-100 minutes after initial dose and then 0.01 mg/kg every 25-60 minutes.

Neuromuscular blockade in the ICU: 0.05-0.1 mg/kg bolus followed by 0.8-1.7 mcg/kg/minute once initial recovery from bolus observed or 0.1-0.2 mg/kg every 1-3 hours

Renal Dosing

dialysis Elimination half-life is doubled, plasma clearance is reduced, and rate of recovery is sometimes much slower.
[CRCL 10-50 ml/min]: Administer 50% of normal dose.
[<10 ml/min]: Do not use.

Hemodialysis

dialysis Do not use.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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