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Ophthalmic Agents - Antibacterials and Combination Products

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besifloxacin ophthalmic susp -Besivance™ --
Ciprofloxacin (Ciloxan ®) Erythromycin (Ilotycin ®)
gatifloxacin ophthalmic solution -ZYMAXID™ Gentamcyin (Garamycin ®)
levofloxacin (Quixin ®) Neosporin ® (neomycin, bacitracin, polymixin )
norfloxacin (Chibroxin ®) Ofloxacin (Ocuflox ®)
Polytrim (polymixin B - trimethoprim) Polysporin ® (polymixinB-bacitracin)
Sulfacetamide (Bleph-10 ®, Sulamyd ®) Tobramycin (Tobrex ®)
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Antibacterial & Corticosteroid Combinations

Blephamide ® (sodium sufacetamide + prednisolone) Cortisporin ® (neomycin, polymixin, HC 1%)
Maxitrol ® (dexamethasone + neomycin + polymixin) Pred G ® (gentamicin + prednisolone)
TobraDex ® (Tobramycin + dexamethasone)  
Please see package insert for additional information and possible updates. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.    [  Read the disclaimer    |   <<Back    |    New drug index   ]

besifloxacin ophthalmic susp -Besivance™ top of page

INDICATIONS AND USAGE
Besivance™ (besifloxacin ophthalmic suspension) 0.6%, is a quinolone antimicrobial indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following bacteria:

CDC coryneform group G

Corynebacterium pseudodiphtheriticum*, Corynebacterium striatum*, Haemophilus influenzae, Moraxella lacunata*, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis*, Staphylococcus lugdunensis*, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumoniae, Streptococcus salivarius*

*Efficacy for this organism was studied in fewer than 10 infections.

DOSAGE AND ADMINISTRATION
Instill one drop in the affected eye(s) 3 times a day, four to twelve hours apart for 7 days.

HOW SUPPLIED
7.5 mL size bottle filled with 5 mL of besifloxacin ophthalmic suspension, 0.6%

HOW SUPPLIED/STORAGE AND HANDLING
Besivance™ (besifloxacin ophthalmic suspension) 0.6%, is supplied as a sterile ophthalmic suspension in a white low density polyethylene (LDPE) bottle with a controlled dropper tip and tan polypropylene cap. Tamper evidence is provided with a shrink band around the cap and neck area of the package.

5 mL in 7.5 mL bottle
NDC 24208-446-05

Ciprofloxacin (Ciloxan ®)  top of page

Adult (usual)
Use 1 drop every 1 to 6 hours or ½" ointment 2 to 3 times daily.

Supplied
: [0.3% ointment, solution]

Erythromycin (Ilotycin ®) top of page

 Adult (usual): ½" of ointment every 3 to 4 hours or use 2 to 4 times daily.

Supplied: [ointment 0.5%]

Gentamcyin (Garamycin ®)  top of page

Adult (usual): 1-2 drops every 4 hours or ½" ointment 2 to 3 times daily.

Supplied: [0.3% oint/soln]

levofloxacin  (Quixin ®) top of page

Adult (usual):  Dosing: Conjunctivitis: days 1-2, 1-2 drops every 2 hr while awake (Max 8 times/day); days 3-7, 1-2 drops every 4 hr while awake (Max 4 times/day) . [Supplied: 0.5% solution. ]

Neosporin ®  (neomycin, bacitracin, polymixin ):  top of page

Adult (usual): Dosing: 1-2 drops every 1 to 6 hours or ½" ointment every 3 to 4 hours.

norfloxacin (Chibroxin ®)  top of page

Adult (usual): Dosing -adults and pediatric patients(> 1 year old) conjunctivitis: 1 or 2 drops applied topically to the affected eye(s) 4 times daily for up to 7 days. Depending on the severity of the infection, the dosage for the first day of therapy may be one or two drops every two hours during the waking hours.

Supplied: [0.3% soln].

Ofloxacin (Ocuflox ®) top of page

Adult (usual):  Dosing: 1-2 drops every 1 to 6 hours depending on severity.

Supplied: [0.3% soln]

Polysporin ® (polymixin B + bacitracin): top of page

Adult (usual):  Ointment. Dosage and Administration: conjunctivitis: Apply the ointment every 3 or 4 hours for 7 to 10 days, depending on the severity of the infection.

Polytrim (polymixin B + trimethoprim): top of page

Adult (usual):  Dosing: 1 drop every 3 to 6 hours. Maximum: 6 drops/day.

Sulfacetamide (Bleph-10 ®, Sulamyd ®) top of page

Adult (usual):  Dosing: 1-2 drops every 2 to 6 hours or ½" ointment every 3 to 8 hours.

Tobramycin (Tobrex ®)  top of page

Adult (usual):  Dosing: 1-2 drops every 1 to 4 hours or ½" ointment every 3 to 4 hours or 2 to 4 times daily 

Supplied: [0.3% oint/soln]






Antibacterial & Corticosteroid Combinations:  top of page

Blephamide ® (sodium sufacetamide + prednisolone):  top of page

Adult (usual): A steroid/anti-infective combination is indicated for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists. SHAKE WELL BEFORE USING.
(Solution): Two drops should be instilled into the conjunctival sac q4h during the day and at bedtime.
(Ointment) Apply 1/2 inch ribbon of ointment in the conjunctival sac three or four times daily and once or twice at night. Not more than 8 g should be prescribed initially.

Cortisporin ® (neomycin, polymixin, HC 1%):  top of page

Adult (usual): Dosing: 1-2 drops or ½" ointment every 3 to 4 hours or more.

Maxitrol ® (dexamethasone + neomycin + polymixin):  top of page

Adult (usual):  Dosing: 1-2 drops every 1 to 8 hours or ½ to 1 inch ointment once or twice daily.


Pred G ® (gentamicin + prednisolone):  top of page

Adult (usual)
Suspension
: Instill one drop into the conjunctival sac two to four times daily. During the initial 24 to 48 hours, the dosing frequency may be increased, if necessary, up to 1 drop every hour. Care should be taken not to discontinue therapy prematurely. If signs and symptoms fail to improve after two days, the patient should be re-evaluated. Supplied: PRED-G® (gentamicin 0.3% - prednisolone acetate 1.0% ophthalmic suspension)
Ointment: A small amount ( 1 / 2 inch ribbon) of ointment should be applied in the conjunctival sac one to three times daily. Care should be taken not to discontinue therapy prematurely.
Supplied
:  PRED-G® (gentamicin 0.3% and prednisolone acetate 0.6% ophthalmic ointment)

TobraDex ® (Tobramycin + dexamethasone):  top of page

Adult (usual):  Dosing: 1-2 drops every 2 to 6 hours or ½" ointment 2 to 4 times daily.


Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.
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