NON-STEADY STATE    -     Dosing By Levels

Patient-Specific Data
Patient:     Location:
dose by levels  
 

Current Levels Data
1st level - Concentration:  mcg/ml    1st level (number hours post dose): hr
2nd level - Concentration: mcg/ml    2nd level (number hours post dose):  hr
3rd level - Concentration: mcg/ml   3rd level (number hours post dose): hr

Current Drug Regimen
Current dose being given:  mg     Current dosing interval: (hours)
Current infusion time (hours):
Desired peak: mcg/ml     Desired trough: mcg/ml
Sample problem to aid filling out the table above
Patient is receiving Gentamicin 120mg IVPB q8h. Infusion time is 30 minutes. A peak is drawn 1 hour after the start of the infusion and a trough is drawn 5 hours after the start of the infusion (note the entries below). The program will take into account the infusion time when calculating the actual peak (do not subtract the infusion time from the number of hours post dose). This program assumes that information provided is based on steady state. If you were to calculate these values by hand, the actual Cmax would occur at the end of the infusion. In this example (t)= 1- 0.5 = 0.5. The Cmin calculation would use a time value of (8 - 5 = 3 hours).

kinetic form


pharmacokinetics

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.

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