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Intravenous Dilution Guidelines

Moxifloxacin (Avelox ®)

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.    PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

Not applicable - Premix Bags - 0.8% saline

Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]

[ 400 mg ] [ 250 ml ] [ 1 hour ]

Premix Bags: AVELOX I.V. (moxifloxacin hydrochloride in sodium chloride injection) is available in ready-to-use 250 mL latex-free flexible bags containing 400 mg of moxifloxacin in 0.8% saline. NO FURTHER DILUTION OF THIS PREPARATION IS NECESSARY.

Stability / Miscellaneous

Stability data:

Drug Stability
Refrigerated
Stability
Room Temp.
Reconstituted
Vial/Powder
Notes P-Insert
Updated
Avelox - Moxifloxacin Do not refrigerate – product precipitates upon refrigeration Store at 25°C (77°F); excursions permitted to 15–30°C (59–86°F) Solution 07 26 16

Label
: DO NOT REFRIGERATE – PRODUCT PRECIPITATES UPON REFRIGERATION

AVELOX I.V. should be administered by INTRAVENOUS infusion only.

DOSAGE AND ADMINISTRATION: The dose of AVELOX is 400 mg (orally or as an intravenous infusion) once every 24 hours.

For Complicated Intra-Abdominal Infections, therapy should be initiated with the intravenous formulation. When switching from intravenous to oral dosage administration, no dosage adjustment is necessary. Patients whose therapy is started with AVELOX I.V. may be switched to AVELOX Tablets when clinically indicated at the discretion of the physician.

Infection Daily Dose Duration
Acute Bacterial Sinusitis 400 mg 10 days
Acute Bacterial Exacerbation of Chronic Bronchitis 400 mg 5 days
Community Acquired
Pneumonia
400 mg 7-14 days
Uncomplicated Skin and Skin Structure Infections 400 mg 7 days
Complicated Skin and Skin Structure Infections 400 mg 7-21 days
Complicated Intra-Abdominal Infections 400 mg 5-14 days

Impaired Renal Function: No dosage adjustment is required in renally impaired patients, including those on either hemodialysis or continuous ambulatory peritoneal dialysis.


Parenteral drug products should be inspected visually for particulate matter prior to administration. Samples containing visible particulates should not be used.

Since the premix flexible containers are for single-use only, any unused portion should be discarded. Store at 25°C (77°F); excursions permitted to 15–30°C (59–86°F) [see USP Controlled Room Temperature].

Source: Bayer Pharmaceuticals. Avelox (moxifloxacin) [package insert]. West Haven, CT; 2007.
Disclaimer
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.  PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
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