The usual dosage of minocycline hydrochloride tablets is 200 mg initially
followed by 100 mg every 12 hours. Alternatively, if more frequent doses are
preferred, two or four 50 mg tablets may be given initially followed by one 50
mg tablet four times daily.
Uncomplicated gonococcal infections other than urethritis and anorectal
infections in men: 200 mg initially, followed by 100 mg every 12 hours
for a minimum of four days, with post-therapy cultures within 2 to 3 days.
In the treatment of uncomplicated gonococcal urethritis in men, 100 mg every 12
hours for 5 days is recommended.
For the treatment of syphilis, the usual dosage of minocycline
hydrochloride should be administered over a period of 10 to 15 days. Close
follow-up, including laboratory tests, is recommended.
In the treatment of meningococcal carrier state, the
recommended dosage is 100 mg every 12 hours for five days.
Mycobacterium marinum infections: Although optimal doses have
not been established, 100 mg every 12 hours for 6 to 8 weeks have been used
successfully in a limited number of cases.
Uncomplicated urethral, endocervical, or rectal infection in adults
caused by Chlamydia trachomatis or Ureaplasma urealyticum: 100 mg
orally, every 12 hours for at least seven days.
Ingestion of adequate amounts of fluids along with capsule and tablet forms of
drugs in the tetracycline-class is recommended to reduce the risk of esophageal
irritation and ulceration.
Manufacturer recommends lower doses (specific regimen not
mentioned). blood level should not exceed 15 mcg/ml. Consider decreasing
dose or increasing dosing interval; total daily dose should not exceed
The pharmacokinetics of minocycline in patients with renal impairment
(CLCR <80mL/min) have not been fully characterized. Current data are
insufficient to determine if a dosage adjustment is warranted. The total
daily dosage should not exceed 200 mg in 24 hours. However, due to the
anti-anabolic effect of tetracyclines, BUN and creatinine should be
Specific recommendations not available.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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