Overview: Renal Insufficiency:
Magnesium is excreted solely by the kidney.
In patients with severe renal insufficiency (e.g. < 30 ml/min), the dose
should be lower and frequent serum magnesium levels must be obtained
Caution should be used when replacing magnesium in any patient with
Magnesium balance is primarily a kidney function (magnesium intake does
not appear to be regulated). The average diet provides 20 - 30 mEq
daily, but the net absorption is only about 7 mEq. The kidneys normally
excrete an equal amount in order to maintain the magnesium balance.
However, in the presence of magnesium deficiency urinary magnesium
excretion can be reduced to a minimum of about 2 mEq/day. Renal
magnesium reabsorption takes place primarily in the proximal
tubule (30% of the filtered load) and the thick ascending limb of
Henle's loop (65%). Overall renal reabsorption appears to be saturable,
so that a higher magnesium intake results in a proportional increase in
urinary excretion. For this reason, it is difficult for patients with
normal renal function to develop hypermagnesemia.
See comments above.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
judgment. Neither GlobalRPh Inc. nor any other party involved in the
preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER
BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU
AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read