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Lamivudine - Epivir ® - Renal Dosing

Usual Dosing (Adults)

HIV: 150mg po q12h or 300mg po qd.
Hepatitis B (Epivir-HBV ®): 100mg po qd.

Combivir ®: [150mg lamivudine/ 300mg AZT]: 1 tablet bid.

Renal Dosing

dialysis Lamivudine-Epivir ®:
HIV:
[CRCL > 50]: No changes
[30-49]: 150mg po qd.
[15-29]: 150mg po x 1, then 100mg po qd.
[5-14]: 150mg x 1, then 50mg qd.
[<5]: 50mg x 1, then 25mg qd.

Hepatitis B:
[CRCL > 50]: No changes
[30-49]: 100mg po x 1, then 50mg po qd.
[15-29]: 100mg po x 1, then 25mg po qd.
[5-14]: 35mg po x 1, then 15mg po qd.
[<5]: 35mg po x 1, then 10mg po qd.

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Lamivudine/Zidovudine - Combivir ®:
[CRCL >50 ml/min]:  No changes.
[<50]:Give each agent separately and adjust based on respective renal dosing guidelines.

Hemodialysis

dialysis Lamivudine- Epivir ®:
HIV: 50mg x 1, then 25-50mg qd.
Hepatitis B: 35mg po x 1, then 10mg po qd.

Lamivudine/Zidovudine - Combivir ®:
Give each agent separately and adjust based on respective renal dosing guidelines.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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