Human Insulin Isophane Suspension. Cloudy/ milky suspension of human
insulin with protamine and zinc.
NPH + Aspart (Novolog ®):
Compatible - NovoLog should be drawn into the syringe first. The
injection should be made immediately after mixing.
NPH + Lispro (Humalog ®): Compatible - Humalog should
be drawn into the syringe first. The injection should be made
immediately after mixing.
NPH +Regular insulin: Always draw the Regular (clear)
insulin into the syringe first.
Phosphate-buffered insulins ( NPH insulin) should NOT be mixed with
lente insulins. Zinc phosphate may precipitate, and the longer-acting
insulin will convert to a short-acting insulin to an unpredictable
extent. Currently available NPH and short-acting insulin formulations
when mixed may be used immediately or stored for future use.
NPH HUMAN INSULIN Description
Humulin N [Human insulin (rDNA origin) isophane suspension] is a crystalline
suspension of human insulin with protamine and zinc providing an
intermediate-acting insulin with a slower onset of action and a longer duration
of activity (up to 24 hours) than that of Regular human insulin. The time course
of action of any insulin may vary considerably in different individuals or at
different times in the same individual. As with all insulin preparations, the
duration of action of Humulin N is dependent on dose, site of injection, blood
supply, temperature, and physical activity. Humulin N is a sterile suspension
and is for subcutaneous injection only. It should not be used intravenously or
intramuscularly. The concentration of Humulin N is 100 units/mL (U–100).
Novolin N InnoLet
It is a cloudy or milky suspension of human insulin with protamine and zinc. The
insulin substance (the cloudy material) settles at the bottom of the insulin
reservoir, therefore, the Novolin N InnoLet must be rotated up and down so that
the contents are uniformly mixed before a dose is given. Novolin N has an
intermediate duration of action. The effect of Novolin N
begins approximately 1.5 hours after injection. The effect is maximal between 4
and 12 hours. The full duration of action may last up to 24 hours after
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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