iv bag
HEMATIN (PANHEMATIN ®)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.    PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
Sterile water

Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]
313 mg vial/ 43 ml
[Prescribed dose] [10-15 min]

(See comments)

Stability / Miscellaneous
Mix just before use / Must use 0.22 micron filter.
Final concentration: 7 mg/ml or @ 301 mg/ 43 ml per manufacturer.

Remove entire volume with a syringe and add the "amount ordered" back into the vial.

Mix just before use (undergoes rapid decomposition).
Usual dose: 1 to 4 mg/kg/day. Maximum dose: 6 mg/kg.

Mechanism of action:
Heme acts to limit the hepatic and/or marrow synthesis of porphyrin (likely due to inhibition of aminolevulonic acid synthetase-the enzyme which limits the rate of porphyrin synthesis.)

Nursing instruction: (1) flush the line with normal saline (2) Add a 0.22 micron filter to the line-must be used because the solution is not transparent and any undissolved particulate matter is difficult to see. (3) Infuse Hematin over 10 to 15 minutes. (4) Use normal saline as a backflush to complete the infusion. Note: the filter will be stained dark brown.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.    PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.