Age related changes in absorption


Many changes occur in the gastrointestinal tract with age:
(1) Increased gastric emptying time

(2) Decreased salivary flow

(3) Decreased absorptive capacity of
         intestinal cells

(4) Decreased gastric acid secretion

(5) Reduced gastrointestinal motility.

(6)Reduced splanchnic blood flow.
Despite these changes, there is little change in drug absorption with age. The rate of absorption may change, but the extent does not. It important to note that any adverse effect observed with drug therapy cannot be attributed to altered drug absorption with age, because no clinically important changes occur.

Geriatric issues

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Feely J, Coakley D.  Altered pharmacodynamics in the elderly.  Clin Geriatric Med. 1990; 6:269-283.

Greenblatt DJ, Sellers EM, Koch-Weser J. Importance of protein binding for the interpretation of serum or plama drug concentrations. J Clin Pharmacol. 1982;22:259-263.

Hammarlund ER, Ostrom JR, Kethley AJ. The effects of drug counseling and other educational strategies on drug utilization in the elderly. Med Care. 1985;23:165-170.

Hanlon JT, Schmader KE, Koronkowski Mj, et al.  Adverse drug events in high risk older patients. J Am Geriatr Soc. 1997; 45(8):945-8.

Frontera WR, Hughes VA, Lutz KJ, Evans WJ. A cross-sectional study of muscle strength and mass in 45- to 78-year-old men and women. J Appl Physiol. 1991;71:644-650.

Lamy PP. Physiological changes due to age: pharmacodynamic changes of drug action and implications of therapy.  Drugs Aging. 1991;1:385-404.

Levy RA.  Therapeutic inequivalence of pharmaceutical alternates.  Amer Pharm.  1985; April: 28-39.

MacLennan WJ, Martin P, Mason BJ. Protein intake and serum albumin levels in the elderly. Gerontology. 1977;23:360-367.

Schmucker DL. Aging and drug disposition: An update. Pharmacol Rev. 1985;37:133-148.

Thoreson J. Drug Metabolism and Drug/Drug Interactions from a Geriatrics Perspective. Clin Ger. 1997; 5: 57-74.

Tregaskis BF, Stevenson IH.  Pharmacokinetics in old age.  Br Med Bulletin. 1990; 46: 9-21.

Wilcox SM, Himmelstein, Inappropriate drug prescribing for the community-dwelling elderly. JAMA. 1994; 272:292-296  


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