Ganciclovir (CYTOVENE) - renal dosing

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Ganciclovir
Cytovene Ž

Usual Dosing (Adults)

CMV retinitis:
(IV) Induction: 5 mg/kg q12h x 14-21 days. Maintenance: 5 mg/kg q24h.
(Oral) 1 gram q8h or 500mg q3h (6x/day). Take with food.

Renal Dosing

[CRCL > 70]: No change

[50-69]: IV: (Induction): 2.5mg/kg q12h. (Maint): 2.5mg/kg q24h.
Oral: 1500mg qd or 500mg tid.

[25-49]: IV: (Induction): 2.5mg/kg q24h. (Maint): 1.25 mg/kg q24h.
Oral: 1000mg qd or 500mg bid.

[10-24]: IV: (Induction): 1.25 mg/kg q24h. (Maint): 0.625 mg/kg q24h.
Oral: 500mg qd.

[<10]: IV: (Induction): 1.25 mg/kg 3x/week following dialysis. (Maint): 0.625 mg/kg 3x/week following dialysis.
Oral: 500mg 3x/week following dialysis.

Hemodialysis

Hemodialysis & peritoneal dialysis:
IV: (Induction): 1.25 mg/kg 3x/week following dialysis.
(Maint): 0.625 mg/kg 3x/week following dialysis.
Oral: 500mg 3x/week following dialysis.