Gabapentin - Neurontin Ž

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Gabapentin
Neurontin Ž

Usual Dosing (Adults)

Usual initial dose: 300mg q8h. Usual maintenance dose: 300-600mg q8h. Maximum dosage/day: 3600 mg

Renal Dosing

[>60 ml/min]: Give usual dosage

[30-59]: Dosage range: 400-1400mg/day
(divided doses - Usually bid)

[15-29]: Dosage range: 200-700mg/day.

[<15]: 100-300 mg/day. Use lower end of this range for CRCL <7.5 ml/min.

Hemodialysis

Hemodialysis:
[<15 ml/min]: 100-300 mg/day. Give supplemental dose of 125-350mg after each dialysis. Dosage given should be proportional to maintenance dose. Patients receiving at least 300mg/day can be given the higher supplemental dose of 350mg after each dialysis. Other patients should receive a dosage at the lower end of this range.

**Neurontin Ž Dosage Based on Renal Function**
Renal Function Creatinine Clearance (mL/min)	Total Daily Dose Range (mg/day)	Dose Regimen (mg)
>/= 60	900-3600	300 TID	400 TID	600 TID	800 TID	1200 TID
>30-59 >15-29 15	400-1400 200-700 100-300	200 BID 200 QD 100 QD	300 BID 300 QD 125 QD	400 BID 400 QD 150 QD	500 BID 500 QD 200 QD	700 BID 700 QD 300 QD
		Post-Hemodialysis Supplemental Dose (mg)
Hemodialysis		125	150	200	250	350
For patients with creatinine clearance <15 mL/min, reduce daily dose in proportion to creatinine clearance (e.g., patients with a creatinine clearance of 7.5 mL/min should receive one-half the daily dose that patients with a creatinine clearance of 15 mL/min receive). Patients on hemodialysis should receive maintenance doses based on estimates of creatinine clearance as indicated in the upper portion of the table and a supplemental post-hemodialysis dose administered after each 4 hours of hemodialysis as indicated in the lower portion of the table.