INDICATIONS AND USAGE
Flucytosine is indicated only in the treatment of serious infections caused by
susceptible strains of Candida and/or Cryptococcus.
DOSAGE AND ADMINISTRATION
The usual dosage of Flucytosine is 50 to 150 mg/kg/day administered in divided
doses at 6-hour intervals. Nausea or vomiting may be reduced or avoided if the
capsules are given a few at a time over a 15-minute period. If the BUN or the
serum creatinine is elevated, or if there are other signs of renal impairment,
the initial dose should be at the lower level (see package insert for WARNINGS).
Flucytosine should be used in combination with amphotericin B for the treatment
of systemic candidiasis and cryptococcosis because of the emergence of
resistance to Flucytosine
[CRCL >40] No change
[20-40]: 12.5 to 37.5 mg/kg q12h.
[10-20]: 12.5 to 37.5 mg/kg q24h.
[<10]: 12.5 to 37.5 mg/kg q24-48h.
Give usual dose (12.5 – 37.5mg/kg) after each dialysis.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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