Epidural Preparations

Common agents: bupivacaine, fentanyl, ropivacaine

Determine volume of epidural additives:

Volumes listed below assume a final volume of 250 ml.   If a volume other than 250ml is requested and any of the following additives are required (bupivacaine, fentanyl - alone or in combination), use our Popup calculator

Using this chart:
Example order

Epidural:  0.125% bupivacaine with fentanyl concentration of 2 mcg/ml.
Using the table below, this would require 62.5 ml of bupivacaine and 10 ml of fentanyl for a total volume of 62.5 + 10 = 72.5ml.   Remove 72.5 ml from a 250 ml bag and then add the additives listed above for a total volume of 250 ml.
Bupivacaine 0.5% vials (preservative-free):
Desired concentration Volume needed
0.0625% 31.25 ml
0.075% 37.5 ml
0.1% 50 ml
0.125 % 62.5 ml
Bupivacaine 0.25% vials (preservative-free):
Desired concentration Volume needed
0.0625% 62.5 ml
0.075% 75 ml
0.1% 100 ml
0.125 % 125 ml
Ropivacaine 0.5% vials (preservative-free):
Desired concentration Volume needed
0.2% (preferred) 100ml
Ropivacaine 1.0% ampule (preservative-free):
Desired concentration Volume needed
0.2% (preferred) 50 ml
Fentanyl 50 mcg/ml  (preservative-free):
Desired concentration Volume needed
2 mcg/ml 10 ml
5 mcg/ml 25 ml
7.5 mcg/ml 37.5 ml
10 mcg/ml 50 ml
Hydromorphone 10 mg/ml  (preservative-free):
  Look carefully at vial - many contain sodium metabisulfite which cannot be used.
Desired concentration Volume needed
25 mcg/ml 0.625 ml
50 mcg/ml 1.25 ml
75 mcg/ml 1.875 ml
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Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.
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