logo

Enoxaparin - Lovenox © - Renal dosing

Usual Dosing (Adults)

DVT prophylaxis (hip / knee surgery): 30 mg SC every 12 hours starting 12-24 hours postop. Alternative for hip: 40 mg SC once daily starting 12 hours preop.   

DVT treatment (Outpatient): 1 mg/kg SC every 12 hours until oral anticoagulation established.  

DVT treatment (Inpatient): 1 mg/kg SC every 12 hours or 1.5 mg/kg SC once daily.  
 
Unstable angina or non-Q-wave MI: 1 mg/kg SC every 12 hours

Prophylaxis in acute medically ill patients (high risk): 40 mg SC qd x 6-11 days (up to 14 days).

Renal Dosing

dialysis [CRCL >30 ml/min]: No specific adjustment recommended (per manufacturer). 

[CRCL < 30 ml/min]:
DVT prophylaxis in abdominal surgery, hip replacement, knee replacement, or in medical patients during acute illness: 
30mg SC qd.

DVT treatment (inpatient or outpt treatment in conjunction with warfarin):  1 mg/kg SC q24h.

Unstable angina, non-Q-wave MI (with ASA): 1 mg/kg SC q24h.

Hemodialysis

dialysis Enoxaparin has not been FDA approved for use in dialysis patients. It's elimination is primarily via the renal route. Serious bleeding complications have been reported with use in patients who are dialysis dependent or have severe renal failure.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
more Career Center image description
Medical Calculators - A thru Z
Lab Values - A thru Z