The recommended dosage of SUSTIVA (efavirenz) is 600 mg orally, once daily, in
combination with a protease inhibitor and/or nucleoside analogue reverse
transcriptase inhibitors (NRTIs). It is recommended that SUSTIVA be taken on an
empty stomach, preferably at bedtime. The increased efavirenz concentrations
observed following administration of SUSTIVA with food may lead to an increase
in frequency of adverse reactions. Dosing at bedtime may improve the
tolerability of nervous system symptoms.
Concomitant Antiretroviral Therapy
SUSTIVA must be given in combination with other antiretroviral medications.
If SUSTIVA is coadministered with voriconazole, the voriconazole maintenance
dose should be increased to 400 mg every 12 hours and the SUSTIVA dose should be
decreased to 300 mg once daily using the capsule formulation (one 200-mg and two
50-mg capsules or six 50-mg capsules). SUSTIVA tablets should not be broken.
If SUSTIVA is coadministered with rifampin to patients weighing 50 kg or more,
an increase in the dose of SUSTIVA to 800 mg once daily is recommended
No adjustments needed
National Institutes of Health, U.S. National Library of Medicine,
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Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
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