Maintenance of Normal Sinus Rhythm (Delay in AF/AFl Recurrence)
TIKOSYN is indicated for the maintenance of normal sinus rhythm (delay in time
to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with
atrial fibrillation/atrial flutter of greater than one week duration who have
been converted to normal sinus rhythm. Because TIKOSYN can cause life
threatening ventricular arrhythmias, it should be reserved for patients in whom
atrial fibrillation/atrial flutter is highly symptomatic.
In general, antiarrhythmic therapy for atrial fibrillation/atrial flutter aims
to prolong the time in normal sinus rhythm. Recurrence is expected in some
patients (see CLINICAL STUDIES).
Conversion of Atrial Fibrillation/Flutter
TIKOSYN is indicated for the conversion of atrial fibrillation and atrial
flutter to normal sinus rhythm.
TIKOSYN has not been shown to be effective in patients with paroxysmal atrial
500 mcg po bid initially. May be initiated at lower doses based on physician
discretion. QTc interval should be measured 2-3 hours after the initial dose. If
the QTc >15% of baseline, or if the QTc is >500 msec (550 msec in patients with
ventricular conduction abnormalities), dofetilide should be adjusted. Continued
monitoring for doses 2-5: QTc interval must be determined 2-3 hours after each
subsequent dose of dofetilide for in-hospital doses 2-5. If the measured QTc is
>500 msec (550 msec in patients with ventricular conduction abnormalities)
dofetilide should be stopped.
[CRCL >60 ml/min]: 500 mcg bid
[40-60 ml/min]: 250 mcg twice daily.
[20-39 ml/min]: 125 mcg twice daily.
[<20 ml/min]: Contraindicated.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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