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Disopyramide - Norpace ® - Renal Dosing

Usual Dosing (Adults)

<50 kg: 100 mg q6h or 200 mg q12h (controlled release)

>50 kg: 150 mg q6h or 300 mg q12h (controlled release); if no response, may increase to 200 mg q6h; maximum dose required for patients with severe refractory ventricular tachycardia is 400 mg q6h.

Renal Dosing

dialysis [>40 ml/min]: No changes
[30-40]: 100 mg q8h
[15-30]: 100mg q12h
[<15 ml/min]: 100mg q24h

Alternative:
[30-40 ml/min]: Reduce dose 50%
[15-30 ml/min]: Reduce dose 75%

Hemodialysis

dialysis 100mg q24h (Not dialyzable)

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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