Decongestants

Phenylephrine  (Neo-Synephrine®):

For OTC use as symptomatic relief of nasal and nasopharyngeal mucosal congestion

Mechanism of Action
Potent, direct-acting alpha-adrenergic stimulator with weak beta-adrenergic activity; causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva; activates the dilator muscle of the pupil to cause contraction; produces vasoconstriction of arterioles in the body; produces systemic arterial vasoconstriction

Nasal congestion: (ORAL)
Dosing (adult): 10mg (1 tablet) every 4 hours as needed. Maximum: 60mg per day. Sample product: Sudafed PE™

Nasal decongestant (therapy should not exceed 3 continuous days):
Children:
6-12 years: Instill 1-2 sprays or instill 1-2 drops every 4 hours of 0.25% solution as needed

Children >12 years and Adults: Instill 1-2 sprays or instill 1-2 drops every 4 hours of 0.25% to 0.5% solution as needed; 1% solution may be used in adult in cases of extreme nasal congestion; do not use nasal solutions more than 3 days

Pseudoephedrine (Sudafed):

Dosing (adult):  Congestion: 30 to 60 mg orally every 4 to 6 hours as needed. Maximum 240mg/day.

Temporary symptomatic relief of nasal congestion due to common cold, upper respiratory allergies, and sinusitis; also promotes nasal or sinus drainage

Mechanism of Action
Directly stimulates alpha-adrenergic receptors of respiratory mucosa causing vasoconstriction; directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility

Dosing
Oral:  Children:
6-12 years: 30 mg every 6 hours; maximum: 120 mg/24 hours

Adults: 30-60 mg every 4-6 hours, sustained release: 120 mg every 12 hours; maximum: 240 mg/24 hours

SUPPLIED:
Gelcap (Dimetapp® Decongestant): 30 mg
Liquid, as hydrochloride:
Triaminic® Allergy Congestion: 15 mg/5 mL (120 mL) [contains benzoic acid]
Syrup, as hydrochloride: 30 mg/5 mL (120 mL, 480 mL)
Tablet, as hydrochloride: 30 mg, 60 mg
Tablet, extended release, as hydrochloride:
Dimetapp® 12-Hour Non-Drowsy Extentabs®, Sudafed® 12 Hour: 120 mg
Sudafed® 24 Hour: 240 mg

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.