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Phenylephrine (Neo-Synephrine®): |
| For OTC use as symptomatic relief of nasal and nasopharyngeal
mucosal congestion Mechanism of Action Potent, direct-acting alpha-adrenergic stimulator with weak beta-adrenergic activity; causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva; activates the dilator muscle of the pupil to cause contraction; produces vasoconstriction of arterioles in the body; produces systemic arterial vasoconstriction Nasal congestion: (ORAL) Dosing (adult): 10mg (1 tablet) every 4 hours as needed. Maximum: 60mg per day. Sample product: Sudafed PE™ Nasal decongestant (therapy should not exceed 3 continuous days): Children: 6-12 years: Instill 1-2 sprays or instill 1-2 drops every 4 hours of 0.25% solution as needed Children >12 years and Adults: Instill 1-2 sprays or instill 1-2 drops every 4 hours of 0.25% to 0.5% solution as needed; 1% solution may be used in adult in cases of extreme nasal congestion; do not use nasal solutions more than 3 days |
Pseudoephedrine (Sudafed): |
|
Dosing (adult): Congestion: 30 to 60 mg orally
every 4 to 6 hours as needed. Maximum 240mg/day. Temporary symptomatic relief of nasal congestion due to common cold, upper respiratory allergies, and sinusitis; also promotes nasal or sinus drainage Mechanism of Action Directly stimulates alpha-adrenergic receptors of respiratory mucosa causing vasoconstriction; directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility Dosing Oral: Children: 6-12 years: 30 mg every 6 hours; maximum: 120 mg/24 hours Adults: 30-60 mg every 4-6 hours, sustained release: 120 mg every 12 hours; maximum: 240 mg/24 hours SUPPLIED: Gelcap (Dimetapp® Decongestant): 30 mg Liquid, as hydrochloride: Triaminic® Allergy Congestion: 15 mg/5 mL (120 mL) [contains benzoic acid] Syrup, as hydrochloride: 30 mg/5 mL (120 mL, 480 mL) Tablet, as hydrochloride: 30 mg, 60 mg Tablet, extended release, as hydrochloride: Dimetapp® 12-Hour Non-Drowsy Extentabs®, Sudafed® 12 Hour: 120 mg Sudafed® 24 Hour: 240 mg |
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Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
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