logo

Cimetidine (Tagamet) - Renal dosing

Usual Dosing (Adults)

Treatment: 800mg qhs, or 300mg PO/IV q6h, or 400mg q12h.
Maintenance: 400 mg qhs.
Esophagitis/reflux: 800mg bid or 400mg po q6h.
Maximum dose/day: 2400 mg.

Renal Dosing

dialysis [>50 ml/min]: No changes.
[10-50]: Give 75% of usual dose at usual interval.
[<10 ml/min]: Give 50% of usual dose at usual interval.

Alternative:
PO:
[>30 ml/min]: no change
[15-30]: usual dose q8h
[<15]: usual dose q12h
IV:
[>50 ml/min]: 300mg q6h
[30-50]: 300mg q8h
[10-29]: 300mg q12h
[<10]: 300mg q24h

Hemodialysis

dialysis [<10]: Give 50% of usual dose at usual interval. Some sources recommend giving 300mg 24h.  Doses should be scheduled after dialysis on dialysis days.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
more Career Center image description
Medical Calculators - A thru Z
Lab Values - A thru Z