Usual: 1-2 grams q12h.
[Life-threatening]: 3 grams IV q12h. General Guidelines for Dosage of CEFOTAN
Frequency and Route
pneumoniae skin and skin structure infections should be treated with
1 or 2 grams every 12 hours IV or IM.
Maximum daily dosage should not exceed 6 grams.
500 mg every 12 hours IV or
1 or 2 g every 24 hours IV or IM
2 g every 12 hours IV or IM
Skin & Skin Structure
Mild - Moderate
2 g every 24 hours IV
1 g every 12 hours IV or IM
2 g every 12 hours IV
2 - 4 grams
1 or 2 g every 12 hours IV or
2 g every 12 hours IV
3 g every 12 hours IV
If Chlamydia trachomatis is a suspected pathogen in gynecologic infections,
appropriate antichlamydial coverage should be added, since cefotetan has no
activity against this organism.
To prevent postoperative infection in clean contaminated or potentially
contaminated surgery in adults, the recommended dosage is 1 or 2 g of CEFOTAN
administered once, intravenously, 30 to 60 minutes prior to surgery. In patients
undergoing cesarean section, the dose should be administered as soon as the
umbilical cord is clamped.
[CRCL >30 ml/min]: No changes
[10-30 ]: 1-2g q24h or 500mg-1g q12h
[<10 ml/min]: 1-2 grams q48h or 250-500mg q12h
250 - 500 mg q24h on non-HD days and 500 mg - 1 gm q24h on HD days
PD: 1 gram q24h
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
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