[Uncomplicated]: 1 gram IV/IM q12h.
[Moderate to severe]: 1-2 grams IV/IM q8h.
[Severe]: 2 grams IV q6-8h.
[Life-threatening]: 2 grams IV q4h GUIDELINES FOR DOSAGE OF CLAFORAN
Type of Infection
Daily Dose (grams)
cervicitis in males and females
0.5 gram IM (single dose)
Rectal gonorrhea in females
0.5 gram IM (single dose)
Rectal gonorrhea in males
1 gram IM (single dose)
1 gram every 12 hours IM or IV
Moderate to severe infections
1–2 grams every 8 hours IM or IV
Infections commonly needing
antibiotics in higher dosage (e.g., septicemia)
2 grams every 6–8 hours IV
up to 12
2 grams every 4 hours IV
If C. trachomatis is a suspected pathogen, appropriate anti-chlamydial coverage
should be added, because cefotaxime sodium has no activity against this
To prevent postoperative infection in contaminated or potentially contaminated
surgery, the recommended dose is a single 1 gram IM or IV administered 30 to 90
minutes prior to start of surgery.
Cesarean Section Patients: The first dose of 1 gram is
administered intravenously as soon as the umbilical cord is clamped. The second
and third doses should be given as 1 gram intravenously or intramuscularly at 6
and 12 hours after the first dose.
Neonates, Infants, and Children: The following dosage schedule
Neonates (birth to 1 month):
0–1 week of age 50 mg/kg per dose every 12 hours IV
1–4 weeks of age 50 mg/kg per dose every 8 hours IV
It is not necessary to differentiate between premature and normal-gestational
Infants and Children (1 month to 12 years):
For body weights less than 50 kg, the recommended daily dose is 50 to 180 mg/kg
IM or IV body weight divided into four to six equal doses. The higher dosages
should be used for more severe or serious infections, including meningitis. For
body weights 50 kg or more, the usual adult dosage should be used; the maximum
daily dosage should not exceed 12 grams.
Dosing recommendations for this drug in renal impairment have
changed over the years. Here is the most recent comments from the
package insert (Nov 2012):
Because high and prolonged serum antibiotic concentrations can occur
from usual doses in patients with transient or persistent reduction of
urinary output because of renal insufficiency, the total daily dosage
should be reduced when CLAFORAN is administered to such patients.
Continued dosage should be determined by degree of renal impairment,
severity of infection, and susceptibility of the causative organism.
Although there is no clinical evidence supporting the necessity of
changing the dosage of cefotaxime sodium in patients with even profound
renal dysfunction, it is suggested that, until further data are
obtained, the dose of cefotaxime sodium be halved in patients with
estimated creatinine clearances of <20 mL/min/1.73 m2.
Note: earlier guidelines recommended interval extension, however, the
newer guidelines do not mention interval changes ... just dosage
No specific guidance available per package insert except for what is
500mg to 2 grams q24h, plus give a supplemental dose post-dialysis.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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