logo

Cefazolin - Ancef ® - Renal Dosing

Usual Dosing (Adults)

[Usual]: 500mg to 1g IV q8h. 
[Moderate to severe]: 500mg – 1 gram q6-8h. 
[life-threatening]: 1–1.5g q6h. 
[Maximum dosage/day]: 12 grams.

DOSAGE AND ADMINISTRATION
Usual Adult Dosage
Type of Infection Dose Frequency
Moderate to severe infections 500 mg to 1 gram every 6 to 8 hrs.
Mild infections caused by susceptible gram-positive cocci 250 mg to 500 mg every 8 hours
Acute, uncomplicated urinary tract infections 1 gram every 12 hours
Pneumococcal pneumonia 500 mg every 12 hours
Severe, life-threatening infections (e.g., endocarditis, septicemia)* 1 gram to 1.5 grams every 6 hours

*In rare instances, doses of up to 12 grams of ANCEF per day have been used.

Renal Dosing

dialysis [CRCL >55 ml/min]: no change.

[35-54 ml/min]: Maximum interval: q8h. 500mg – 1.5g q8h.

[11-34 ml/min]: 500mg – 1.5g x 1, then 0.5 - 1 gram q12h.

[<10 ml/min]: 500 mg - 1 gram q18-24h.

Dosage Adjustment for Patients With Reduced Renal Function
ANCEF may be used in patients with reduced renal function with the following dosage adjustments: Patients with a creatinine clearance of 55 mL/min. or greater or a serum creatinine of 1.5 mg % or less can be given full doses. Patients with creatinine clearance rates of 35 to 54 mL/min. or serum creatinine of 1.6 to 3.0 mg % can also be given full doses but dosage should be restricted to at least 8 hour intervals. Patients with creatinine clearance rates of 11 to 34 mL/min. or serum creatinine of 3.1 to 4.5 mg % should be given 1/2 the usual dose every 12 hours. Patients with creatinine clearance rates of 10 mL/min. or less or serum creatinine of 4.6 mg % or greater should be given 1/2 the usual dose every 18 to 24 hours. All reduced dosage recommendations apply after an initial loading dose appropriate to the severity of the infection.

Hemodialysis

dialysis 500 mg – 1 gram IV q24h. (Give dose post-dialysis on dialysis days.)

PD: 500 mg q12h.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
Medical Calculators - A thru Z
Lab Values - A thru Z