*In rare instances, doses of up to 12 grams of ANCEF per day have been used.
[CRCL >55 ml/min]: no change.
[35-54 ml/min]: Maximum interval: q8h. 500mg – 1.5g q8h.
[11-34 ml/min]: 500mg – 1.5g x 1, then 0.5 - 1 gram q12h.
[<10 ml/min]: 500 mg - 1 gram q18-24h. Dosage Adjustment for Patients With
Reduced Renal Function
ANCEF may be used in patients with reduced renal function with the
following dosage adjustments: Patients with a creatinine clearance of
55 mL/min. or greater or a serum creatinine of 1.5 mg %
or less can be given full doses. Patients with creatinine clearance
rates of 35 to 54 mL/min. or serum creatinine of 1.6 to
3.0 mg % can also be given full doses but dosage should be restricted to
at least 8 hour intervals. Patients with creatinine clearance rates of
11 to 34 mL/min. or serum creatinine of 3.1 to 4.5 mg %
should be given 1/2 the usual dose every 12 hours. Patients with
creatinine clearance rates of 10 mL/min. or less or
serum creatinine of 4.6 mg % or greater should be given 1/2 the usual
dose every 18 to 24 hours. All reduced dosage recommendations apply
after an initial loading dose appropriate to the severity of the
500 mg – 1 gram IV q24h. (Give dose post-dialysis on dialysis days.)
PD: 500 mg q12h.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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