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Burn preparations: (topical)
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mafenide acetate (Sulfamylon ®)
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Use - Adjunct in the
treatment of second- and third-degree burns to prevent septicemia caused
by susceptible organisms such as Pseudomonas aeruginosa Orphan drug: Prevention of graft loss of meshed autografts on excised burn wounds Mechanism of Action - Interferes with bacterial folic acid synthesis through competitive inhibition of para-aminobenzoic acid Dosing: Children and Adults: Topical: Apply once or twice daily with a sterile gloved hand; apply to a thickness of approximately 16 mm; the burned area should be covered with cream at all times Supplied Cream, topical, as acetate: 85 mg/g (60 g, 120 g, 454 g) [contains sodium metabisulfite] Powder, for topical solution: 5% (5s) [50 g/packet] |
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silver sulfadiazine (SSD ® , Silvadene ®)
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Use - Prevention and
treatment of infection in second and third degree burns Mechanism of Action - Acts upon the bacterial cell wall and cell membrane. Bactericidal for many gram-negative and gram-positive bacteria and is effective against yeast. Active against Pseudomonas aeruginosa , Pseudomonas maltophilia , Enterobacter species, Klebsiella species, Serratia species, Escherichia coli , Proteus mirabilis , Morganella morganii , Providencia rettgeri , Proteus vulgaris , Providencia species, Citrobacter species, Acinetobacter calcoaceticus , Staphylococcus aureus , Staphylococcus epidermidis , Enterococcus species, Candida albicans , Corynebacterium diphtheriae , and Clostridium perfringens Dosing Children and Adults: Topical: Apply once or twice daily with a sterile-gloved hand; apply to a thickness of 1 /16"; burned area should be covered with cream at all times Supplied Cream, topical: 1% [10 mg/g] (25 g, 85 g, 400 g) Silvadene®, Thermazene®: 1% (20 g, 50 g, 85 g, 400 g, 1000 g) SSD®: 1% (25 g, 50 g, 85 g, 400 g) SSD AF®: 1% (50 g, 400 g) |
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Disclaimer |
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Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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GlobalRPH does not directly or indirectly practice medicine or provide
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kind for the information and data accessed through the Service or for
any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
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