Bivalirudin - Angiomax ®

Bivalirudin - Angiomax ® - Renal dosing

Usual Dosing (Adults)

Anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA).

Dosing: Initially, IV bolus: 0.75 mg/kg, followed by an infusion of 1.75 mg/kg/hour for the duration of the procedure. Determine ACT 5 minutes after bolus dose has been administered. Continuation of the Angiomax infusion following PCI for up to 4 hours post-procedure is optional, at the discretion of the treating physician. After 4 hours, an additional IV infusion of Angiomax may be initiated at a rate of 0.2 mg/kg/h for up to 20 hours, if needed.

Renal Dosing

Initial bolus dose remains unchanged. Monitor activated coagulation time (ACT).
[> 30 ml/min]: No adjustment required
[10-29 ml/min]: Decrease infusion rate to 1 mg/kg/hour.

Hemodialysis

Dialysis-dependent patients (off dialysis): Decrease infusion rate to 0.25 mg/kg/hour. No reduction in the bolus dose is needed.

Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer

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