DOSAGE AND ADMINISTRATION
The initial dose of Kerlone in hypertension is ordinarily 10 mg once daily
either alone or added to diuretic therapy. The full antihypertensive effect is
usually seen within 7 to 14 days. If the desired response is not achieved the
dose can be doubled after 7 to 14 days. Increasing the dose beyond 20 mg has not
been shown to produce a statistically significant additional antihypertensive
effect; but the 40-mg dose has been studied and is well tolerated. An increased
effect (reduction) on heart rate should be anticipated with increasing dosage.
If monotherapy with Kerlone does not produce the desired response, the addition
of a diuretic agent or other antihypertensive should be considered
Patients with renal failure
In patients with renal impairment, clearance of betaxolol declines with
decreasing renal function.
In patients with severe renal impairment and those undergoing dialysis
the initial dose of Kerlone is 5 mg once daily. If the desired response
is not achieved, dosage may be increased by 5 mg/day increments every 2
weeks to a maximum dose of 20 mg/day.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
judgment. Neither GlobalRPh Inc. nor any other party involved in the
preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER
BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU
AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read