Aztreonam - Azactam ® - Renal dosing

Usual Dosing (Adults)

[Mild infection] (i.e. UTI): 500mg to 1 gram IV q8-12h.
[Usual dose]: 1-2 grams IV q8-12h.
[Severe/life threatening infection]: 2 grams IV q6-8h.

[Maximum dose]: 8 grams/day.

Renal Dosing

IV:
[CRCL >30 ml/min]: no change.

[10-30 ml/min]: Loading dose: 1-2 grams x 1, then give 50% of the usual dose (e.g. 0.5 – 1 gm) q6-12h.

[<10 ml/min]: 1–2 grams x 1, then 25% of usual dose (e.g. 250-500 mg) q6-12 hours.

Hemodialysis

Hemodialysis:
1 – 2 grams x 1, then 25% of usual dose q6-12h. (e.g., 250-500 mg q6-12 hours).
For serious or life-threatening infections, give an additional 125mg after each hemodialysis session (1/8th of the usual dose).

PD:
1 – 2 grams x 1, then 25% of usual dose q6-12h. (e.g., 250-500 mg q6-12 hours).

Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer

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