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Pulmonary Medications | ||||||||||||||||
| Anticholinergics | Beta-2 agonists | Combination products | Corticosteroids | Leukotriene Inhibitors | Mast cell stabilizers | Other | ||||||||||||||||
| Anticholinergics [TOP] | ||||||||||||||||
|
ipratropium |
Blocks the
action of acetylcholine at parasympathetic sites in bronchial smooth muscle
causing bronchodilation. Adult (usual): Nebulization: 500 mcg (one vial) 3-4 times/day with doses 6-8 hours apart. Metered dose inhaler: 2 puffs 4 times/day - up to 12 puffs /24 hours. Supplied: Nebulization (soln): 0.02% (2.5 ml). MDI: 18 mcg/actuation. |
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|
tiotropium |
Anticholinergic agent
(bronchodilator). Adult (usual): COPD: Oral inhalation: Contents of 1 capsule (18 mcg) inhaled once daily using HandiHaler® device. |
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| Beta-2 agonists (short acting) [TOP] | ||||||||||||||||
|
albuterol |
Beta-2 Agonist.
Adult (usual): Asthma: 1-2 puffs every 4-6 hours as needed. Maximum: 12 inhalations/day.
Prophylaxis of exercise-induced bronchospasm: MDI: 2 puffs 5-30 minutes prior to exercise. Nebulized 2.5 mg 3-4 times daily. Tablets: 2-4 mg orally 3-4 times daily. Sustained release tablets: 4-8 mg q12h (Maximum dose: 32 mg/day). Acute treatment of bronchospasm: MDI (90 mcg/puff): 4-8 puffs every 20 minutes for up to 4 hours, then every 1-4 hours as needed. Nebulization: 2.5 mg (3ml) 3-4 times/day over 5-15 minutes. Bronchospasm in ICU patients (acute): Nebulization: 2.5-5 mg every 20 minutes for 3 doses, then 2.5-10 mg every 1-4 hours as needed, or 10-15 mg/hour continuously. |
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|
bitolterol | (Beta-2
agonist):
Adult (usual): Bronchospasm, acute: MDI 2 puffs separated by
1-3 minutes, follow with third as needed. Bronchospasm,
prevention: MDI, 2 puffs q8h, Maximum of 3 puffs q6h or 2
puffs q4h. Bronchospasm, prevention: (intermittent flow nebulizer) 0.5-1 ml (1-2 mg) 3-4 times per day (Maximum of 8 mg/day). Bronchospasm, prevention: (continuous flow nebulizer) 1.25 ml (2.5 mg) 3-4 times/day. (Maximum of 14 mg/day). Supplied [0.8% aerosol. 0.2% (2 mg/ml) inhalation Soln]. |
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| levalbuterol Xopenex ® |
Beta-2 agonist. Adult (usual):
Bronchospasm: MDI: Aerosol: 1-2 puffs every 4-6 hours.
Nebulization: 0.63 mg 3 times/day at intervals of 6-8 hours. Dosage
may be increased to 1.25 mg 3 times/day with close monitoring for adverse
effects. Most patients gain optimal benefit from regular use.
|
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| pirbuterol Maxair ® | Adult (usual): Asthma: 1-2 puffs every 4-6 hours (up to 12 puffs/day). | |||||||||||||||
|
metaproterenol |
Adult (usual): Asthma, bronchospasm: 20 mg orally 3-4 times/day. Oral aerosol inhalation: 2-3 puffs q3-4 hours (Max of 12 puffs/day). Nebulizer: 0.3 ml (5%) in 2.5 ml NS q4-6 hours prn. | |||||||||||||||
| Beta-2 agonists (Long acting) [TOP] | ||||||||||||||||
| formoterol Foradil ® | (Long-acting
Beta-2 agonist): Adult (usual): Asthma (maintenance therapy): Oral inhalation - 12 mcg (1 capsule) q12h via aerolizer inhaler. (Maximum of 24 mcg/day). COPD: Oral inhalation 12 mcg (1 capsule) q12h via aerolizer inhaler. Exercise-induced bronchospasm (EIB): 12 mcg (1 capsule) at least 15 min before exercise as needed. Supplied: [12 mcg capsule] |
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| salmeterol Serevent ® | MDI:
Inhale
2
puffs twice a day. (Do not exceed). Serevent Diskus: Asthma: usual dosage for adults and children 4 years of age and older is 1 inhalation (50 mcg) twice daily (morning and evening, approximately 12 hours apart). If symptoms arise in the period between doses, an inhaled, short-acting beta 2 -agonist should be taken for immediate relief. COPD: usual dosage for adults is 1 inhalation (50 mcg) twice daily (morning and evening, approximately 12 hours apart). Prevention of Exercise-Induced Bronchospasm (EIB): One inhalation at least 30 minutes before exercise. Additional doses should not be used for 12 hours after the administration of this drug. If regular, twice-daily dosing is not effective in preventing EIB, other appropriate therapy for EIB should be considered. |
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| Combination (Beta2 agonist + Anticholinergic) [TOP] | ||||||||||||||||
| Combivent ® albuterol + ipratropium | Adult (usual): COPD: (MDI): 2 inhalations 4 times daily (Max of 12 puffs/day). Inhalation solution: one 3 ml vial via nebulization 4 times daily (Max of 6 doses/day). | |||||||||||||||
| Combination (Beta2 agonist + Corticosteroid) [TOP] | ||||||||||||||||
| Advair ® fluticasone + salmeterol |
Adult (usual): Asthma: 1 puff twice daily (morning and evening) approximately 12 hours
apart. More frequent administration (more than twice daily) or a
higher number of inhalations (more than 1 puff twice daily) is not recommended. [Supplied: Advair Diskus: 100/50, 250/50 ,500/50 ] |
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| Symbicort ® budesonide + formoterol | Adult (usual): 1-2 inhalations once or twice daily (Maximum daily maintenance dose: 4 inhalations). Maximum dose during worsening asthma: 4 inhalations twice daily. [Supplied: 100/6 and 200/6] | |||||||||||||||
| beclomethasone Vanceril ® Beclovent ® | Inhale 2 puffs 3 to 4 times daily or 4 puffs twice a day. | |||||||||||||||
|
budesonide |
Adult (usual): Asthma: 1-4 puffs twice daily (Max of 4 puffs bid). Note: patients with mild symptoms may be converted to once daily administration (1-2 puffs qd). [Supplied: MDI 200 mcg/inhalation] | |||||||||||||||
| flunisolide Aerobid ® | inhale 2-4 puffs twice a day. | |||||||||||||||
| fluticasone Flovent ® | Inhale 2-4 puffs twice a day. Supplied: [44,110,220 mcg] | |||||||||||||||
| mometasone furoate Asmanex ® | In-vitro
studies show that mometasone is similar in potency to fluticasone and more
potent than budesonide, beclomethasone, and triamcinolone. Adult (usual): Asthma:
HOW TO USE - Remove
the ASMANEX TWISTHALER from its foil pouch and write the date on the cap
label. It’s important to throw away the inhaler 45 days after this date
or when the dose counter reads “00,” whichever comes first. |
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| triamcinolone Azmacort ® | inhale: 2 puffs 3 to 4 times a day or 4 puffs twice a day. Maximum: 16 puffs/day. | |||||||||||||||
| montelukast Singulair ® | Leukotriene Receptor Antagonist.
Adult (usual): Asthma or allergic seasonal rhinitis: 10
mg orally once daily in the evening. Supplied: 10 mg tablet. 4mg, 5mg chewable tablet. |
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| zafirlukast Accolate ® | 20 mg orally twice daily between meals. | |||||||||||||||
| zileuton Zyflo ® | 600 mg orally 4 times a day. | |||||||||||||||
| cromolyn sodium Intal ® | Inhale 2 puffs 4 times a day. | |||||||||||||||
| nedocromil Tilade ® | Inhale 2 puffs 4 times a day. | |||||||||||||||
| acetylcysteine Mucomyst ® Acetadote ® | Mucolytic
agent. Adjuvant therapy in respiratory
conditions: Note: Patients should receive
bronchodilator 15 minutes prior to dose. Inhalation, nebulization: 10% and 20% solution.
Dilute 20% solution with sodium chloride or sterile water for inhalation.
10% solution may be used undiluted: 3-5 ml of 20% solution or 6-10 ml of 10%
solution until nebulized - given 3-4 times/day. Dosing range: 1-10 ml of 20%
solution or 2-20 ml of 10% solution every 2-6 hours. Into tracheostomy: 1-2
ml of 10% to 20% solution every 1-4 hours. |
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| aminophylline /theophylline: | Maximum rate: 25 mg/min.
IV loading: 5 mg/kg TBW based on theophylline or 6 mg/kg based on
aminophylline. Previous therapy: [Loading dose= 0.5 L/kg TBW x (desired level - current level)] IV maintenance dose based on IBW and theophylline. For aminophylline dosing divide result by 0.8. Adult non-smoker: 0.4 mg/kg/hr Adult (smoker): 0.7 mg/kg/hr Elderly (smoker): 0.5 mg/kg/hr Elderly (non-smoker)/ CHF/ Liver disease: 0.2 mg/kg/hr. Obtain level 24-48 hours after initiation of therapy. Average half-life: 3 to 12 hrs. Vd: 0.5 L/kg. Therapeutic range: 5-20 mcg/ml. IVPB is the least desirable route of admin. It is less effective than a continuous infusion. IVPB-cyclic improvement is seen at the peak with a rapid decline towards the trough. |
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|
Listed dosages are for - Adult
patients ONLY.
PLEASE
READ THE DISCLAIMER
CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR
USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS
SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or
indirectly practice medicine or provide medical services and
therefore assumes no liability whatsoever of any kind for the
information and data accessed through the Service or for any
diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
|
Comparable
Daily Doses for Inhaled Corticosteroids |
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|
A D U L T S |
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|
Drug |
Low Dose |
Medium Dose |
High Dose |
|
Beclomethasone dipropionate |
168 – 504 mcg |
504 – 840 mcg |
>840 mcg |
| 42 mcg/puff | (4-12 puffs – 42 mcg) | (12-20 puffs – 42 mcg) | (>20 puffs – 42 mcg) |
| 84 mcg/puff | (2-6 puffs – 84 mcg) | (6-10 puffs – 84 mcg) | (>10 puffs – 84 mcg) |
|
Budesonide |
200
– 400 mcg |
400
– 600 mcg |
>600
mcg |
|
Flunisolide |
500
– 1000 mcg |
1000
– 2000 mcg |
>2000
mcg |
|
Fluticasone |
88 – 264 mcg |
264 – 660 mcg |
>660 mcg |
| MDI: 44, 110, 220 mcg/puff |
(2-6 puffs – 44 mcg OR 2 puffs – 110 mcg) |
(2-6 puffs – 110 mcg) |
(>6 puffs – 110 mcg OR >3 puffs – 220 mcg) |
| DPI: 50, 100, 250 mcg/dose | (2-6 inhalations – 50 mcg) | (3-6 inhalations – 100 mcg) |
(>6 inhalations – 100 mcg OR >2 inhalations – 250 mcg) |
|
Triamcinolone
acetonide |
400
– 1000 mcg |
1000
– 2000 mcg |
>2000
mcg |
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|
CHILDREN |
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|
Drug |
Low Dose |
Medium Dose |
High Dose |
|
Beclomethasone dipropionate |
84 – 336 mcg |
336 – 672 mcg |
>672 mcg |
| 42 mcg/puff | (2-8 puffs – 42 mcg) | (8-16 puffs – 42 mcg) | (>16 puffs – 42 mcg) |
| 84 mcg/puff | (1-4 puffs – 84 mcg) | (4-8 puffs – 84 mcg) | (>8 puffs – 84 mcg) |
|
Budesonide |
100 – 200 mcg |
200
– 400 mcg |
>400
mcg |
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|
Flunisolide |
500
– 750 mcg |
1000
– 1250 mcg |
>1250
mcg |
|
Fluticasone |
88 – 176 mcg |
176 – 440 mcg |
>440 mcg |
| MDI: 44, 110, 220 mcg/puff | (2-4 puffs – 44 mcg) |
(4-10 puffs – 110 mcg OR 2-4 puffs – 110 mcg) |
(>4 puffs – 110 mcg, OR >2 puffs – 220 mcg) |
| DPI: 50, 100, 250 mcg/dose | (2-4 inhalations – 50 mcg) | (2-4 inhalations – 100 mcg) |
(>4 inhalations – 100 mcg OR >2 inhalations – 250 mcg) |
|
Triamcinolone
acetonide |
400
– 800 mcg |
800
– 1200 mcg |
>1200
mcg |
DPI = dry powder inhaler MDI = metered dose inhaler |
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