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TB

Tuberculosis - therapeutic agents

NEW MONOGRAPHS

Ethambutol Dosing: 15-25 mg/kg up to 2500 mg orally once daily.
Isoniazid Adults: 5mg/kg/day PO (maximum 300mg);or  15mg/kg (maximum 900mg) 2-3 times weekly.
Pyrazinamide Adults: 15 to 30 mg/kg/day (maximum of 2 grams daily). Alternative regimen:  50 to 70 mg/kg two or three times weekly (maximum 3 grams/dose).
rifabutin (Mycobutin):  300 mg orally once daily or 150 mg orally twice a day given with a meal.
Rifamate (INH 150mg + rifampin 300mg): Take 2 capsules orally once daily 1 hour before or 2 hours after a meal.  (2 capsules = 600 mg rifampin, 300 mg isoniazid)
Rifampin TB: 10-20 mg/kg up to 600 mg oral or IV once daily. 
Synergy gram (+): (900-1200 mg/day in 3 divided doses): Usual dose: 300 mg orally every 8 hours. Some recommend 600 mg orally once daily.
rifapentine (Priftin):  Cyclopentyl derivative of rifampin (longer duration of action and greater efficacy compared to rifampin). Dosing:  600 mg orally twice weekly x 2 months, then once weekly x 4 months. (Twice weekly if HIV).
Rifater ( INH50mg+rif 120mg +pyr300mg): Dosing: 6 tabs orally once daily (if > 55kg). 5 tabs orally once daily if < 55 kg.  (Take 1 hour before or 2 hours after a meal with a full glass of water.)

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References - Infectious Disease Section

Infectious Disease References

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The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
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