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Pneumonia (VAP)

Ventilator-associated pneumonia (VAP)

(Mild to moderate infection AND multi-drug resistance unlikely): Common pathogens
Ceftriaxone 1-2 grams IV q24h  OR
Ampicillin-sulbactam (Unasyn) 3.0 grams ivpb q6h  OR
Levofloxacin 750 mg IV/PO once daily OR
Ertapenem 1 gm IV q24h

PLUS (If MRSA suspected)
Vancomycin
- (patient-specific regimen - trough goal 15-20 mcg/ml)
(Severe infection OR multi-drug resistance LIKELY): Common pathogens
Cefepime 2 grams IV every 12 hours OR
Piperacillin-tazobactam 4.5 grams IV Q6H OR
Meropenem 1 gm IV q8h

PLUS
Vancomycin
- (patient-specific regimen - trough goal 15-20 mcg/ml)

PLUS
Ciprofloxacin
400mg IV q8h  OR
Levofloxacin 750 mg IV/PO once daily OR
Aminoglycoside (Tobra) - patient-specific regimen.

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References - Infectious Disease Section

Infectious Disease References

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
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