Anti-herpetic agents. Herpes Simplex. Anti-viral agents.

Pericarditis

Acyclovir ( Zovirax ® )	famciclovir ( Famvir ®)
valacyclovir ( Valtrex ®)	Topical Products

Acyclovir ( Zovirax ® ) (back)

Mucocutaneous herpes simplex: IV: 5 mg/kg/dose every 8 hours x 5-10 days.
Encephalitis: 10mg/kg/dose IV every 8 hours.
Primary HSV infection-genital (Oral therapy): 200mg every 4 hours while awake (5 times/day) or 400mg orally three times daily for 10 days.
Recurrent genital: 400mg orally three times daily for 5 days.
Herpes Zoster: 800mg orally every 4 hours while awake (5 times/ day) for 7 days. If severe give 10-12 mg/kg IV every 8 hours x 7-14 days.
Chronic suppression (genital herpes): 400mg orally twice daily.

Zovirax ointment: apply ½" every 3 hours (6 times/day).

Renal dosing: 50 - 90/ 5 to 12.4 mg/kg q8h || 10-50 / 5-12.4 mg/kg q12-24h || <10 / 2.5 to 6 mg/kg q24h. Alternatively: (Oral): 10-25 / dose q8h || <10 / dose q12h. (IV): 25-50/ 5-10mg/kg q12h || 10-25/ 5-10mg/kg q24h || <10/ 2.5 to 5mg/kg IV q24h. || HD: dose after dialysis || CAPD: see < 10.

famciclovir ( Famvir ®) (back)

First episode genital: 250 mg orally three times daily for 7-10 days.
Recurrent herpes simplex (genital): 125 mg orally twice daily for 5 days.
Prophylaxis (Chronic suppression): 250mg orally twice daily.
Recurrent (HIV patient): 500mg orally twice daily for 7 days.
Zoster: 500mg orally three times daily for 7 days.

Supplied: [125,250, 500 mg tabs]

Renal dosing: >60/ no change || 40-59/ 500mg q12h || 11-39/ 500mg q24h || <10/ 250 mg q48h || HD: 250mg after dialysis.

valacyclovir ( Valtrex ®) (back)

First episode genital: 1000mg orally twice daily for 10 days. Recurrent: 500mg orally twice daily for 5 days. Prophylaxis: 500-1000mg orally once daily.
Zoster: 1000 mg orally three times daily for 7 days.
Herpes labialis (cold sores) 2 gm q12h x 1 day.

Supplied: [500,1000mg tabs]

Renal Dosing:
[CRCL >50]: No changes.

[30-49]: Zoster: 1 gram q12h. H. Labialis: 1 gram q12h x 2 doses. Initial episode GH: 1 gram q12h. Recurrent: 500mg q12h. Suppressive: 0.5 – 1 gm qd.

[10-29]: Zoster: 1 gram q24h. H. Labialis (lip): 500mg q12h x 2 doses. Initial episode G. Herpes: 1 gram q24h. Recurrent: 500mg q24h. Suppressive: 500mg q24-48h.

[<10]: Zoster: 500mg q24h. H. Labialis: 500mg x 1.
Initial episode G. Herpes: 500mg q24h. Recurrent: 500mg q24h. Suppressive: 500mg q24-48h. Hemo: 500 mg PO q24h (on dialysis days give dose after dialysis)

Anti-Herpetic (Topical): (back)

acyclovir ( Zovirax ®)

Apply every 3 hours (6 times / day) for 7 days.
Supplied: [5% ointment]

docosanol ( Abreva ®)

Abreva Cream (Docosanol 10%):
Uses: Treats cold sore/fever blisters on the face or lips. Shortens healing time and duration of symptoms: tingling, pain, burning, and/or itching.
Directions: adults and children 12 years or over: wash hands before and after applying cream. Apply to affected area on face or lips at the first sign of cold sore/fever blister (tingle). Early treatment ensures the best results. Rub in gently but completely. Use 5 times a day until healed.

penciclovir ( Denavir ®)

Herpes labialis: apply 1% cream every 2 hours while awake for 4 days.

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc.

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References - Infectious Disease Section

Infectious Disease References

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer