| Anti-Herpetic
agents:
NEW MONOGRAPHS
|
acyclovir
(Zovirax ®): |
| Mucocutaneous herpes
simplex: IV: |
| 5 mg/kg/dose every 8 hours x 5-10 days. |
| Encephalitis: |
|
10mg/kg/dose IV every 8 hours. |
| Primary HSV
infection-genital (Oral therapy): |
| 200mg every 4 hours while awake (5
times/day) or 400mg orally three times daily for 10 days. |
| Recurrent
genital: |
| 400mg orally three times daily for 5 days. |
| Herpes
Zoster: |
| 800mg orally every 4 hours while awake (5 times/ day)
for 7 days. If severe give 10-12 mg/kg IV every 8 hours x 7-14 days. |
|
Chronic suppression (genital herpes): |
| 400mg orally twice daily. |
|
Renal dosing: |
| 50 - 90/ 5 to 12.4 mg/kg q8h || 10-50 / 5-12.4 mg/kg
q12-24h || <10 / 2.5 to 6 mg/kg q24h. Alternatively: (Oral):
10-25 / dose q8h || <10 / dose q12h. (IV): 25-50/ 5-10mg/kg q12h ||
10-25/ 5-10mg/kg q24h || <10/ 2.5 to 5mg/kg IV q24h. || HD: dose after
dialysis || CAPD: see < 10. |
|
famciclovir
(Famvir ® ): |
| First episode
genital: |
| 250 mg orally three times daily for 7-10 days. |
| Recurrent:
|
| 125 mg
orally twice daily for 5 days. |
| Prophylaxis: |
| 250mg orally twice daily. |
|
Recurrent (HIV patient): |
| 500mg orally twice daily for 7 days. |
| Zoster: |
| 500mg orally three times daily for 7 days. |
| Supplied: |
| 125,250, 500
mg tabs |
| Renal dosing: |
| >60/ no change || 40-59/ 500mg q12h ||
11-39/ 500mg q24h || <10/ 250 mg q48h || HD: 250mg after dialysis. |
|
valacyclovir
(Valtrex ®): |
| First episode genital: |
|
1000mg orally twice daily for 10 days. |
| Recurrent: |
| 500mg orally twice daily
for 5 days. |
| Prophylaxis: |
| 500-1000mg orally once daily. |
| Zoster: |
| 1000 mg orally three times daily for 7 days. |
| Supplied:
[500,1000mg tabs] |
|
| Topical
agents |
acyclovir ointment
(Zovirax ®): |
apply ½" every 3 hours (6
times/day). Supplied: [5% ointment] |
penciclovir
(Denavir ®): |
Herpes
labialis:
apply 1% cream every 2 hours while awake for 4 days. |
