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Infection

Decubitus ulcer  Possible therapeutic alternatives
Decubitus ulcer with sepsis Common pathogens
Severe:
Piperacillin-tazobactam
3.375 grams IV every 6 hours 
OR
Ticarcillin-clavulanic acid 3.1 grams IV every 6 hours OR
Doripenem 500 mg IV q8h OR
Meropenem 1 gm IV q8h OR
Imipenem 500mg IV every 6 hours.  OR
[Ciprofloxacin 400mg ivpb q12h or Levofloxacin 500mg ivpb qd] PLUS [Clindamycin 600mg ivpb q6-8h or Metronidazole 500mg ivpb q6-8h.]
Ceftazidime 1-2 grams IV every 8 hours  OR Cefepime 1-2 grams q 12h
PLUS
  Metronidazole 500mg ivpb q6-8h.
Penicillin allergic:
 [Aztreonam 1-2g ivpb q6-8h PLUS
Metronidazole 500mg ivpb q6h ]     ]
Decubitus ulcer (uncomplicated) Common pathogens Ampicillin-sulbactam 1.5-3 grams ivpb q6h OR
Local debridement + antibiotic ointment + moist wound dressing.

Images

Decubitus Ulcer (Ankle)

References - Infectious Disease Section

Infectious Disease References

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
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