Disclaimer - Please see package insert
if applicable for additional information. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.Read the disclaimer
Mucocutaneous herpes simplex: IV: 5 mg/kg/dose every 8
hours x 5-10 days.
Encephalitis: 10mg/kg/dose IV every 8 hours. Primary HSV infection-genital (Oral therapy): 200mg
every 4 hours while awake (5 times/day) or 400mg orally three times
daily for 10 days. Recurrent genital: 400mg orally three times daily for 5
days. Herpes Zoster: 800mg orally every 4 hours while awake
(5 times/ day) for 7 days. If severe give 10-12 mg/kg IV every 8 hours x
7-14 days. Chronic suppression (genital herpes): 400mg orally
Zovirax ointment: apply ½" every 3 hours (6 times/day).
Renal dosing: 50
- 90/ 5 to 12.4 mg/kg q8h || 10-50 / 5-12.4 mg/kg q12-24h || <10 / 2.5
to 6 mg/kg q24h. Alternatively: (Oral): 10-25 / dose q8h || <10 / dose
q12h. (IV): 25-50/ 5-10mg/kg q12h || 10-25/ 5-10mg/kg q24h || <10/ 2.5
to 5mg/kg IV q24h. || HD: dose after dialysis || CAPD: see < 10.
Drug UPDATES: SITAVIG (acyclovir) buccal tablets 50mg
PDF] Dosing: Click (+) next to Dosage and Administration section
(drug info link)
Initial U.S. Approval: 2013
Mechanism of Action: Acyclovir is a synthetic purine nucleoside
that is phosphorylated intracellularly by the viral encoded thymidine kinase
(TK) of HSV into acyclovir monophosphate, a nucleotide analogue. The
monophosphate is further converted into diphosphate by cellular guanylate kinase
and into triphosphate by a number of cellular enzymes. In a biochemical
reaction, acyclovir triphosphate inhibits replication of herpes viral DNA by
competing with nucleotides for binding to the viral DNA polymerase and by
incorporation into and termination of the growing viral DNA chain. The cellular
thymidine kinase of normal, uninfected cells does not use acyclovir effectively
as a substrate, hence toxicity to mammalian host cells is low.
INDICATIONS AND USAGE: SITAVIG (acyclovir) buccal tablets
50mgSITAVIG is indicated for the treatment of recurrent herpes labialis (cold
sores) in immunocompetent adults DOSAGE AND ADMINISTRATION
Application of one SITAVIG 50 mg buccal tablet as a single dose to the upper gum
(canine fossa) region.
SITAVIG should be applied within one hour after the onset of prodromal symptoms
and before the appearance of any signs of herpes labailis.
Do not crush, chew, suck or swallow tablets .
[10-29]: Zoster: 1 gram q24h. H. Labialis (lip): 500mg q12h x 2 doses.
Initial episode G. Herpes: 1 gram q24h. Recurrent: 500mg q24h.
Suppressive: 500mg q24-48h.
[<10]: Zoster: 500mg q24h. H. Labialis: 500mg x 1.
Initial episode G. Herpes: 500mg q24h. Recurrent: 500mg q24h.
Suppressive: 500mg q24-48h. Hemo: 500 mg PO q24h (on dialysis days give
dose after dialysis)
Apply every 3 hours (6 times / day) for 7
days. Supplied: [5% ointment]
docosanol ( Abreva ®)
Abreva Cream (Docosanol 10%):
Uses: Treats cold sore/fever blisters on
the face or lips. Shortens healing time and duration of symptoms:
tingling, pain, burning, and/or itching.
Directions: adults and children
12 years or over: wash hands before and after applying cream. Apply to
affected area on face or lips at the first sign of cold sore/fever
blister (tingle). Early treatment ensures the best results. Rub in
gently but completely. Use 5 times a day until healed.
Herpes labialis: apply 1% cream every 2 hours while awake for
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
Listed dosages are for - Adult patients ONLY. PLEASE READ THE
DISCLAIMER CAREFULLY BEFORE
ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE
TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
GlobalRPH does not directly or indirectly practice medicine or provide
medical services and therefore assumes no liability whatsoever of any
kind for the information and data accessed through the Service or for
any diagnosis or treatment made in reliance thereon.