Angiotensin II Receptor Blockers
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Equivalent Dosages
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Candesartan (Atacand ®):
8 mg |
Eprosartan (Tevetan ®):
400 mg |
Irbesartan (Avapro ®):
75 mg |
Losartan (Cozaar ®):
25 mg |
Olmesartan (Benicar ®):
10 mg |
Telmisartan (Micardis ®):
20 mg |
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Valsartan (Diovan ®):
40 mg |
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Equivalent Dosages
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Candesartan (Atacand ®):
16 mg |
Eprosartan (Tevetan ®):
600 mg |
Irbesartan (Avapro ®):
150 mg |
Losartan (Cozaar ®):
50 mg |
Olmesartan (Benicar ®):
20 mg |
Telmisartan (Micardis ®):
40 mg |
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Valsartan (Diovan ®):
80 mg |
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Candesartan (Atacand ®)
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Supplied: 4 mg, 8 mg, 16 mg, 32 mg
Dosing: Hypertension: Oral: Initial: 16 mg once daily.
Range: 4 to 32 mg once daily. Dosage must be individualized. It can be
administered once or twice daily with total daily doses ranging from 8-32 mg.
CHF: Oral: Initial: 4 mg once daily. Double the dose at 2-week
intervals, as tolerated; target dose: 32 mg. |
Eprosartan (Tevetan ®)
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Supplied: 400 mg, 600 mg
Dosing: Hypertension: Oral:
Usual initial dose is 600 mg once daily. Dosage must be individualized. Can
administer once or twice daily with total daily doses of 400 to 800 mg.
Limited clinical experience with doses greater than 800 mg. |
Irbesartan (Avapro ®)
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Supplied: 75 mg, 150 mg, 300 mg
Dosing: Hypertension: Oral:
150 mg once daily ... patients may be titrated to 300 mg once daily. Note:
Starting dose in volume-depleted patients should be 75 mg. |
Losartan (Cozaar ®)
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Supplied: 25 mg, 50 mg, 100 mg
Dosing: Hypertension: Oral:
Initial: 25 to 50 mg once daily. Can be administered once or twice daily
with total daily doses ranging from 25 to 100 mg. Usual initial
doses in patients receiving diuretics or those with intravascular volume
depletion: 25 mg. |
Olmesartan (Benicar ®)
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Supplied: 5 mg, 20 mg, 40 mg
Dosing: Hypertension: Oral:
Initial: Usual starting dose is 20 mg once daily. If initial response is
inadequate, may be increased to 40 mg once daily after 2 weeks. Consider lower
starting dose in patients with possible volume deficits. |
Telmisartan (Micardis ®):
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Supplied: 20 mg, 40 mg, 80 mg
Dosing: Hypertension: Oral:
Initial: 40 mg once daily. Usual maintenance dose range: 20 to 80 mg per
day. Patients with volume depletion should be initiated on the lower dosage with
close supervision. |
Valsartan (Diovan ®)
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Supplied: 40 mg, 80 mg, 160 mg, 320 mg
Dosing: Hypertension: Initial:
80 mg or 160 mg once daily (in patients who are not volume depleted). Dose may
be increased to achieve desired effect ... maximum recommended dose: 320 mg per
day.
CHF: Initial: 40 mg twice daily.
Titrate dose to 80 to 160 mg twice daily, as tolerated. Maximum daily
dose: 320 mg. Left ventricular
dysfunction after MI: Initial: 20 mg twice daily. Titrate dose
to target of 160 mg twice daily as tolerated. |
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References
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| Atacand [package insert]. Wilmington, DE:
AstraZeneca; February 2007. |
| Avapro [package insert]. New York, NY:
Sanofi-Synthelabo; October 2005. |
| Benicar [package insert]. New York, NY: Sankyo
Pharmaceuticals. Ocotober 2006. |
| Cozaar [package insert]. Whitehouse Station, NJ:
Merck & Co, Inc.; December 2005. |
| Diovan [package insert]. East Hanover, NJ:
Novartis Pharmaceutical Co; June 2007. |
| Drug Facts & Comparisons. St. Louis, MO. Facts &
Comparisons. 2005. |
| Micardis [package insert]. Ridgefield, CT:
Boehringer Ingelheim; November 2003. |
| Teveten [package insert]. Morrisville, NC:
Biovail Pharmaceuticals; September 2005. |
| The authors make no claims of the accuracy of the
information contained herein; and these suggested doses are not a
substitute for clinical judgement. Neither GlobalRPh Inc. nor any other
party involved in the preparation of this program shall be liable for
any special, consequential, or exemplary damages resulting in whole or
part from any user's use of or reliance upon this material.PLEASE READ
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CONDITIONS SET FORTH IN THE DISCLAIMER. |
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