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Amoxicillin - Renal Dosing

Usual Dosing

Adults and Pediatric Patients > 3 Months

* Dosing for infections caused by less susceptible organisms should follow the recommendations for severe infections.
The children’s dosage is intended for individuals whose weight is less than 40 kg. Children weighing 40 kg or more should be dosed according to the adult recommendations.
Infection Severity* Usual Adult Dose Usual Dose for Children >3 Months
Ear/Nose/
Throat
Mild/ Moderate 500 mg every 12 hours or
250 mg every 8 hours
25 mg/kg/day in divided
doses every 12 hours
or
20 mg/kg/day in divided
doses every 8 hours
Severe 875 mg every 12 hours or
500 mg every 8 hours
45 mg/kg/day in divided
doses every 12 hours
or
40 mg/kg/day in divided
doses every 8 hours
Lower Respiratory Tract Mild/ Moderate or Severe 875 mg every 12 hours or
500 mg every 8 hours
45 mg/kg/day in divided
doses every 12 hours
or
40 mg/kg/day in divided
doses every 8 hours
Skin/Skin Structure Mild/ Moderate 500 mg every 12 hours or 250 mg every 8 hours 25 mg/kg/day in divided
doses every 12 hours
or
20 mg/kg/day in divided
doses every 8 hours
Severe 875 mg every 12 hours or 500 mg every 8 hours 45 mg/kg/day in divided
doses every 12 hours
or
40 mg/kg/day in divided
doses every 8 hours
Genitourinary Tract Mild/ Moderate 500 mg every 12 hours or 250 mg every 8 hours 25 mg/kg/day in divided
doses every 12 hours
or
20 mg/kg/day in divided
doses every 8 hours
Severe 875 mg every 12 hours or 500 mg every 8 hours 45 mg/kg/day in divided
doses every 12 hours
or
40 mg/kg/day in divided
doses every 8 hours
Gonorrhea Acute, uncomplicated ano-genital and urethral infections in males and females   3 grams as single oral dose Prepubertal children:
50 mg/kg Amoxicillin, combined with 25 mg/kg probenecid as a single dose.
NOTE: SINCE
PROBENECID IS
CONTRAINDICATED IN CHILDREN UNDER 2 YEARS, DO NOT USE THIS REGIMEN IN THESE CASES.

All patients with gonorrhea should be evaluated for syphilis.

Larger doses may be required for stubborn or severe infections.


Renal Dosing

dialysis PO:
[CRCL >30 ]: No change. 
[10-29 ml/min]: q8-12h. Do not use 875 mg tablet. 
[<10 ml/min]: q24h. Do not use 875mg tablet.

Hemodialysis

dialysis 250 to 500mg q24h plus additional dose after dialysis.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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