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Allopurinol - Zyloprim ® - Renal dosing

Usual Dosing (Adults)

Gout: initially 100mg qd. Increase by 100mg/day q7days, titrate to desired uric acid level. Usual range: (Mild gout): 200-300mg/day. Moderate-severe: 400-600mg/day.

Maximum dose/day: 800mg

Renal Dosing

dialysis Oral:
[>80 ml/min]:  Usual dose
[60 - 80]: 200-250 mg daily
[40 - 60]: 150 - 200mg daily
[20 - 40]: 100 - 150mg daily
[10 - 20]: 100mg q24
[<10 ml/min]: 100 mg q24-48h

Alternatively:
[>50 ml/min]: No changes
[20-50]: 100-300mg q24h.
[10-20]: 100-200mg q24h.
[<10]: 100mg q24-48h.

IV:
[10 - 20 ml/min]: Administer 200 mg/day.
[3 - 10 ml/min]: Administer 100 mg/day.
[<3 ml/min]:  Administer 100 mg/day at extended intervals.

Hemodialysis

dialysis 100mg q24-48h (give dose after dialysis on dialysis days.)

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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