Mucocutaneous herpes simplex: IV: 5 mg/kg/dose every 8 hours x
5-10 days. Encephalitis: 10mg/kg/dose IV every 8 hours. Primary HSV infection-genital (Oral therapy): 200mg every 4
hours while awake (5 times/day) or 400mg orally three times daily for 10 days.
Recurrent genital: 400mg orally three times daily for 5 days. Herpes Zoster: 800mg orally every 4 hours while awake (5 times/
day) for 7 days. If severe give 10-12 mg/kg IV every 8 hours x 7-14 days. Chronic suppression (genital herpes): 400mg orally twice
Patients with Acute or Chronic Renal Impairment: Refer to dosing
info above for recommended doses, and adjust the dosing
interval as indicated in the Table below.
Dosage Adjustments for Patients with Renal
For patients who require dialysis, the mean plasma half-life of
acyclovir during hemodialysis is approximately 5 hours. This results in
a 60% decrease in plasma concentrations following a 6 hour dialysis
period. Therefore, the patient’s dosing schedule should be adjusted so
that an additional dose is administered after each dialysis.
No supplemental dose appears to be necessary after adjustment of the
IV: 2.5 - 5 mg/kg IV q24h (give dose after dialysis
on dialysis days). Oral: See above for <10 ml/min.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
judgment. Neither GlobalRPh Inc. nor any other party involved in the
preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER
BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU
AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read