Acyclovir- Zovirax ® - Renal dosing

Usual Dosing (Adults)

Mucocutaneous herpes simplex: IV: 5 mg/kg/dose every 8 hours x 5-10 days.
Encephalitis: 10mg/kg/dose IV every 8 hours.
Primary HSV infection-genital (Oral therapy): 200mg every 4 hours while awake (5 times/day) or 400mg orally three times daily for 10 days.

Recurrent genital: 400mg orally three times daily for 5 days.
Herpes Zoster: 800mg orally every 4 hours while awake (5 times/ day) for 7 days. If severe give 10-12 mg/kg IV every 8 hours x 7-14 days.
Chronic suppression (genital herpes): 400mg orally twice daily.

Renal Dosing

Oral:
Genital herpes therapy:
[>/= 10]: Usual dose
[<10 ml/min]: 200mg q12h

Genital herpes suppression/prophylaxis:
[>/= 10]: Usual dose
[<10 ml/min]: 200mg q12h

Herpes zoster:
[>25 ml/min]: Usual dose
[10-25]: 800mg q8h
[<10 ml/min]: 800mg q12h

IV:
[>50 ml/min]: No change
[30-50]: 5-10mg/kg q12h
[10-30]: 5-10mg/kg q24h
[<10 ml/min]: 2.5 to 5mg/kg q24h

Hemodialysis

IV: 2.5 - 5 mg/kg IV q24h (give dose after dialysis on dialysis days).
Oral: See above for <10 ml/min.

Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer

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