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Actinic keratosis (topical therapy)
| Actinic keratoses (AKs) are premalignant lesions that develop only on sun-damaged skin. |
declofenac
(Solaraze ®)
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Apply to lesion areas twice daily (smoothed onto the
affected skin gently). Recommended duration of therapy: 60 days to 90
days. Complete healing of the lesion(s) or optimal therapeutic effect
may not be evident for up to 30 days following cessation of therapy.
Lesions that do not respond to therapy should be carefully re-evaluated
and management reconsidered. Appears to be significantly better
tolerated than twice daily application of 5-FU, although it may be
somewhat less effective. [Supplied: Gel: 25 and 50 gram tubes. Each gram of gel contains 30 mg of diclofenac sodium.] |
fluorouracil
(Efudex ®):
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Superficial basal cell carcinomas: apply 5% cream/solution twice daily.
Actinic keratoses: Carac™: Apply thin film to lesions once daily for up to 4 weeks, as tolerated. Efudex®: Apply to lesions twice daily for 2-4 weeks; complete healing may not be evident for 1-2 months following treatment. Fluoroplex®: Apply to lesions twice daily for 2-6 weeks Supplied: Cream, topical: Carac™: 0.5% (30 g). Efudex®: 5% (25 g, 40 g). Fluoroplex®: 1% (30 g). |
Other:
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1) Liquid nitrogen cryotherapy - widely utilized. 2) Chemical peels. 3) Dermabrasion. 4) Surgical (curettage) therapy. |
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any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
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