 |
Acne Treatments
|
||||||||||||||
adapalene
(Differin ®)
|
||||||||||||||
|
Topical retinoid-like compound. Acne vulgaris (adult):
after washing, apply a thin film topically to affected area(s) once
daily at bedtime. [Supplied 0.1% cream/solution/gel] |
||||||||||||||
azelaic acid
(Azelex ®)
|
||||||||||||||
|
Adult (usual) Mild-to-moderate inflammatory acne: apply a
thin film topically to affected area twice daily. Indications: topical
treatment of vulgaris. Azelaic acid is a naturally-occurring, saturated,
straight-chained dicarboxylic acid. [Supplied 20% cream] |
||||||||||||||
BenzaClin ®
|
||||||||||||||
|
Topical Gel. Apply twice daily, morning and evening, or as directed by a
physician, to affected areas after the skin is gently washed, rinsed
with warm water and patted dry. [Supplied: Each gram of BenzaClin Topical Gel contains, 10 mg (1%) clindamycin as phosphate and 50 mg (5%) benzoyl peroxide] |
||||||||||||||
Benzamycin ®
|
||||||||||||||
|
Topical Gel. Apply twice daily, morning and evening, or as directed by a
physician to affected areas after the skin is thoroughly washed, rinsed
with warm water and gently patted dry. [Supplied: Topical gel - erythromycin 3%-benzoyl peroxide 5% ] |
||||||||||||||
Benzoyl Peroxide
|
||||||||||||||
|
Children and Adults: Cleansers: Wash once or twice daily; control amount of drying or peeling by modifying dose frequency or concentration Topical: Apply sparingly once daily; gradually increase to 2-3 times/day if needed. If excessive dryness or peeling occurs, reduce dose frequency or concentration; if excessive stinging or burning occurs, remove with mild soap and water; resume use the next day. [2.5% - 10 %] Mechanism of Action Releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids Benzoyl peroxide is an antibacterial, mildly comedolytic, and sebostatic agent. [Supplied: several dosage forms - gels, creams, suspensions, ...] [2.5% - 10 %] |
||||||||||||||
clindamycin
(Cleocin ®)
|
||||||||||||||
|
Children >/= 12 years and Adults: Topical:
Acne vulgaris: apply thin film of solution, lotion, or gel topically twice daily to affected areas. Note: Foam (Evoclin™): Apply once daily Adverse Reactions - Topical: >10%: Dermatologic: Dryness, burning, itching, scaliness, erythema, or peeling of skin (lotion, solution); oiliness (gel, lotion). 1% to 10%: Central nervous system: Headache. <1% (Limited to important or life-threatening): Pseudomembranous colitis, nausea, vomiting, diarrhea (severe), abdominal pain, folliculitis, hypersensitivity reactions [Supplied: 1% gel/lotion/solution] |
||||||||||||||
Duac ®
|
||||||||||||||
|
Topical Gel. Apply once daily in the evening or as directed by the
physician, to affected areas after the skin is gently washed, rinsed
with warm water and patted dry. [Supplied: 1% clindamycin, and 5% benzoyl peroxide topical gel] |
||||||||||||||
Erythromycin
|
||||||||||||||
|
ERYGEL® 2% Topical Gel should be applied sparingly as a
thin film to affected area(s) once or twice a day after the skin is
thoroughly cleansed and patted dry. If there has been no improvement
after 6 to 8 weeks, or if the condition becomes worse, treatment should
be discontinued, and the physician should be reconsulted. Spread the
medication lightly rather than rubbing it in. There are no data directly
comparing the safety and efficacy of b.i.d. versus q.d. dosing. ERYGEL® 2% topical solution: wash skin with soap and warm water and pat dry. Apply to affected area bid with a dabbing motion. |
||||||||||||||
Glycolic Acid - (BioMedic ® Cellex-C ® Glytone ®
)
|
||||||||||||||
|
Glycolic Acids have been reported to
improve acne, pseudofoliculites, barbae, ichthyosis/xerosis, as well as
premature aging of the skin. Seattle Dermatologist: "Glycolic Acid has been proven to be very effective in the treatment of acne as well as the cosmetic benefits one receives. I feel that the use of glycolic acid, especially for the treatment of acne, is the most exciting development in the field of facial skin care over the past decade. It is my prediction that glycolic acid will soon become the standard treatment approach for acne." |
||||||||||||||
Isotretinoin
(Accutane ®)
|
||||||||||||||
|
Adult (usual) : Severe recalcitrant nodular
acne: 0.5-2 mg/kg/day in 2 divided doses (dosages as low as 0.05
mg/kg/day have been reported to be beneficial) for 15-20 weeks
or until the total cyst count decreases by 70%, whichever is
sooner. A second course of therapy may be initiated after a
period of >/= 2 months off therapy. Dosing adjustment in hepatic impairment: Dose reductions empirically are recommended in hepatitis disease Administration Administer with food. Capsules can be swallowed, or chewed and swallowed. The capsule may be opened with a large needle and the contents placed on applesauce or ice cream for patients unable to swallow the capsule. Whole capsules should be swallowed with a full glass of liquid. Monitoring Parameters CBC with differential and platelet count, baseline sedimentation rate, glucose, CPK Pregnancy test (for all female patients of childbearing potential): Two negative tests with a sensitivity of at least 25 mIU/mL prior to beginning therapy (the second performed during the first five days of the menstrual period immediately preceding the start of therapy); monthly tests to rule out pregnancy prior to refilling prescription. Lipids: Prior to treatment and at weekly or biweekly intervals until response to treatment is established. Test should not be performed <36 hours after consumption of ethanol. Liver function tests: Prior to treatment and at weekly or biweekly intervals until response to treatment is established. [Supplied 10 mg, 20 mg, 40 mg capsule] |
||||||||||||||
Sulfacetamide with sulfur
(Sulfacet-R ®)
|
||||||||||||||
|
Indications: topical control of acne is, acne
rosacea and seborrheic dermatitis. Clean the affected area and apply a
thin layer of medication to the skin 1 to 3 times daily; or use as
directed by your doctor. (Shake Well before using.) Expiration date after reconstituting: four months. [Supplied: sodium sulfacetamide 10% and sulfur 5% topical lotion] |
||||||||||||||
Tazarotene
(Tazorac ®)
|
||||||||||||||
|
Mechanism of Action Synthetic, acetylenic retinoid which modulates differentiation and proliferation of epithelial tissue and exerts some degree of anti-inflammatory and immunological activity ---------------------------------------------- Topical: Note: In patients experiencing excessive pruritus, burning, skin redness, or peeling, discontinue until integrity of the skin is restored, or reduce dosing to an interval the patient is able to tolerate. --------------------------------------------- Children >/= 12 years and Adults: Acne: Tazorac® cream/gel 0.1%: Cleanse the face gently. After the skin is dry, apply a thin film of tazarotene (2 mg/cm 2 ) once daily, in the evening, to the skin where the acne lesions appear; use enough to cover the entire affected area Psoriasis: Tazorac® gel 0.05% or 0.1%: Apply once daily, in the evening, to psoriatic lesions using enough (2 mg/cm 2 ) to cover only the lesion with a thin film to no more than 20% of body surface area. If a bath or shower is taken prior to application, dry the skin before applying. Unaffected skin may be more susceptible to irritation, avoid application to these areas. --------------------------------------------- Children >/= 17 years and Adults: Palliation of fine facial wrinkles, facial mottled hyper/hypopigmentation, benign facial lentigines: Avage™: Apply a pea-sized amount once daily to clean dry face at bedtime; lightly cover entire face including eyelids if desired. Emollients or moisturizers may be applied before or after; if applied before tazarotene, ensure cream or lotion has absorbed into the skin and has dried completely. --------------------------------------------- Adults: Psoriasis: Tazorac® cream 0.05% or 0.1%: Apply once daily, in the evening, to psoriatic lesions using enough (2 mg/cm 2 ) to cover only the lesion with a thin film to no more than 20% of body surface area. If a bath or shower is taken prior to application, dry the skin before applying. Unaffected skin may be more susceptible to irritation, avoid application to these areas. --------------------------------------------- [Supplied 0.05%, 0.1% cream. 0.05%, 0.1% gel] |
||||||||||||||
Tretinoin
(Retin-A ®)
|
||||||||||||||
|
Topical: Children >12 years and
Adults: Acne vulgaris: Begin therapy with a weaker formulation of tretinoin (0.025% cream, 0.04% microsphere gel, or 0.01% gel) and increase the concentration as tolerated; apply once daily to acne lesions before retiring or on alternate days; if stinging or irritation develop, decrease frequency of application --------------------------------------------- Adults >/= 18: Palliation of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin: Pea-sized amount of the 0.02% or 0.05% cream applied to entire face once daily in the evening --------------------------------------------- Elderly: Use of the 0.02% cream in patients 65-71 years of age showed similar improvement in fine wrinkles as seen in patients <65 years. Safety and efficacy of the 0.02% cream have not been established in patients >71 years of age. Safety and efficacy of the 0.05% cream have not been established in patients >50 years of age. --------------------------------------------- Administration Palliation of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin: Cream: Prior to application, gently wash face with a mild soap. Pat dry. Wait 20-30 minutes to apply cream. Avoid eyes, ears, nostrils, and mouth. --------------------------------------------- Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04% - this formulation uses patented methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres (Microsponge® System) to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. Retin-A Micro should be applied once a day, in the evening, to the skin where acne lesions appear, using enough to cover the entire affected area lightly. Application of excessive amounts of gel may result in "caking" of the gel, and will not provide incremental efficacy. Supplied: cream/gel/liquid - various concentrations. |
||||||||||||||
|
|
||||||||||||||
Disclaimer |
||||||||||||||
|
Listed dosages are for - Adult patients ONLY. PLEASE READ THE
DISCLAIMER CAREFULLY BEFORE
ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE
TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
GlobalRPH does not directly or indirectly practice medicine or provide
medical services and therefore assumes no liability whatsoever of any
kind for the information and data accessed through the Service or for
any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
| Disclaimer Contact Us Privacy Policy Website Search | We comply with the HONcode standard for health trustworthy information: Verify here. Copyright © 2007 GlobalRPh Inc. |
 |
 |